Document Detail

Proliferative and secretory activity in the pregnant and lactating human breast.
MedLine Citation:
PMID:  3135656     Owner:  NLM     Status:  MEDLINE    
In this study the proliferative and secretory activity of human pregnant and lactating breast has been examined. 17 cases of pregnant tissue were obtained, comprising 9 from first trimester, 6 from the second and 2 from the third, together with 3 cases of lactating breast. Proliferation, measured by 3H thymidine autoradiography, gave a constant Thymidine labelling index of approximately 6% during the first 20 weeks, with a reduction by 50% thereafter. Levels of 0.2% were seen during lactation. Morphological assessment showed a high frequency of both mitosis and apoptosis throughout gestation. Although mitotic frequency did reduce with time, values were more variable than thymidine labelling. The reduction in thymidine uptake halfway through pregnancy coincided with generalised morphological lactational differentiation and the major immunocytochemical expression of alpha-lactalbumin. However, cytoplasmic expression of the secretory component of IgA was generalised and marked even during the first trimester and was closely related to increased proliferation and general synthetic cellular activity. These and other observations support a complex relationship of autocrine and paracrine factors in addition to the customary endocrine ones for breast regulation.
S Battersby; T J Anderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  413     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1988  
Date Detail:
Created Date:  1988-08-31     Completed Date:  1988-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
Department of Pathology, University of Edinburgh, United Kingdom.
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MeSH Terms
Breast / cytology,  physiology*,  secretion
Cell Division*
Immunoglobulin A, Secretory / analysis
Lactalbumin / analysis
Pregnancy / metabolism,  physiology*
Reg. No./Substance:
0/Immunoglobulin A, Secretory; 9013-90-5/Lactalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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