Document Detail

Proliferative potential and apoptosis in rat glioma cell lines after hyperthermia.
MedLine Citation:
PMID:  9631633     Owner:  NLM     Status:  MEDLINE    
The proliferative potential of cultured rat glioma cells (C6 and 9L) was evaluated after hyperthermia using immunohistochemical staining with bromodeoxyuridine (BrdU) and Ki-67 monoclonal antibodies. Apoptosis was assessed by in situ end-labeling of deoxyribonucleic acid breaks. Both BrdU and Ki-67 labeling indexes decreased with increasing hyperthermia time. The decrease of the Ki-67 labeling index was not as great as that of the BrdU labeling index. The number of apoptotic cells increased with time after hyperthermia. These results indicate that the antitumor effect of hyperthermia may reflect the induction of apoptosis in the cells within the cell cycle, and the resultant reduction of the proliferative potential of surviving cells, especially in the S phase.
R Y Liu; K Matsumoto; K Kunishio; S Mizumatsu; T Tamiya; T Furuta; T Ohmoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  38     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-09     Completed Date:  1998-07-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  196-201; discussion 201-2     Citation Subset:  IM    
Department of Neurological Surgery, Okayama University Medical School.
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MeSH Terms
Apoptosis / physiology*
Cell Division / physiology
Glioma / pathology*
Hyperthermia, Induced*
Tumor Cells, Cultured

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