Document Detail

Proliferative fasciitis: ultrastructure and histogenesis.
MedLine Citation:
PMID:  2760292     Owner:  NLM     Status:  MEDLINE    
The ultrastructure was studied of 2 cases of proliferative fasciitis (PF) which affected the fascia and subcutaneous fat. Two basic cell types were observed in the lesions: fibroblast-like, and giant cells. The fibroblast-like cells had myofibroblastic ultrastructural characteristics. The giant cells showed a well-developed, rough endoplasmic reticulum, irregularly distributed filaments and clear lipid droplets in their cytoplasms. Ultrastructurally, the giant cells seemed to belong to a cellular line capable of synthesizing ground substances and extracellular fibers, but with a modified phenotype. A consistent feature was the presence of nodular aggregates of numerous proliferating perivascular cells. Transitional forms between perivascular, fibroblast-like, and giant cells were observed. Our hypothesis is that perivascular cells (activated pericytes) are the source of the fibroblast-like and giant cells in proliferative fasciitis.
L Diaz-Flores; A I Martin Herrera; R Garcia Montelongo; R Gutierrez Garcia
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  16     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-09-19     Completed Date:  1989-09-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Department of Pathology, La Laguna University, Canary Island, Spain.
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MeSH Terms
Fascia / pathology,  ultrastructure*
Fasciitis / diagnosis,  etiology,  pathology*
Microscopy, Electron
Middle Aged
Comment In:
J Cutan Pathol. 1990 Jun;17(3):189-90   [PMID:  1695640 ]

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