| Proliferative and cytokine responses of human T lymphocytes isolated from human immunodeficiency virus-infected patients to the major surface glycoprotein of Pneumocystis carinii. | |
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MedLine Citation:
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PMID: 9419198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current study examined the proliferative capacity and cytokine secretion pattern of peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus type 1 (HIV-1)-infected patients in response to the major surface glycoprotein (MSG) of Pneumocystis carinii. PBMC from AIDS patients with <200 CD4 cells/mL had significantly less proliferative responses to MSG than did healthy controls. Cytokine analysis indicated that interferon-gamma secreted in response to MSG was also significantly less. There was no significant difference in interleukin-4 levels following incubation with MSG between any of the groups; however, all the HIV-infected persons had slightly elevated levels. When the CDC class C3 patients who had a previous episode of P. carinii pneumonia were compared with those who had not had a previous episode, there was a significant increase in the proliferative response to MSG and in interleukin-4 secretion. CDC class C3 patients who had a previous episode of P. carinii pneumonia showed a predominately Th2 response to MSG. |
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Authors:
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S A Theus; N Sawhney; A G Smulian; P D Walzer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 177 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-01-23 Completed Date: 1998-01-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 238-41 Citation Subset: AIM; IM; X |
Affiliation:
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Cincinnati Veterans Affairs Medical Center, Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45220, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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immunology Acquired Immunodeficiency Syndrome / immunology* Adult CD4 Lymphocyte Count Cell Division Cells, Cultured Female Fungal Proteins / pharmacology* HIV-1* Humans Interferon-gamma / metabolism* Interleukin-4 / metabolism* Leukocytes, Mononuclear / cytology, immunology*, metabolism Male Membrane Glycoproteins / pharmacology* Middle Aged Th2 Cells / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI-25139/AI/NIAID NIH HHS; AI-25897/AI/NIAID NIH HHS; AI-34759/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 0/Membrane Glycoproteins; 151472-24-1/GPA protein, Pneumocystis carinii sp.; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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