Document Detail

Proliferative activity in endometrial hyperplasia and adenocarcinoma.
MedLine Citation:
PMID:  11374806     Owner:  NLM     Status:  MEDLINE    
Studies on the proliferative activity of cells in endometrial hyperplasia and adenocarcinoma were performed using techniques detecting Proliferating Cell Nuclear Antigen (PCNA) and Nucleolar Organizer Regions (NORs). PCNA expression was defined as the percentage of nuclei showing reactivity in 200 cells per sample. The mean AgNOR count per cell was calculated following the analysis of at least 100 nuclei per sample at a magnification of x 400. Student-t test was used for the statistical analysis. The results obtained indicate that the evaluation of cell proliferative activity expressed by AgNOR count and PCNA index can help in the distinction between atypical hyperplasia and well-differentiated adenocarcinoma, and thus can serve as a useful pathological criterion.
S Terlikowski; A Lenczewski; W Famulski; M Sulkowska; M Kulikowski
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  39     ISSN:  0239-8508     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-25     Completed Date:  2001-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  163-4     Citation Subset:  IM    
Department of Gynecology and Septic Obstetrics, Medical Academy, Białystok, Poland.
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MeSH Terms
Adenocarcinoma / pathology*
Antibodies, Monoclonal / diagnostic use
Cell Division
Endometrial Hyperplasia / pathology*
Endometrial Neoplasms / pathology*
Nucleolus Organizer Region / pathology
Proliferating Cell Nuclear Antigen / immunology
Silver Staining
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Proliferating Cell Nuclear Antigen

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