Document Detail

Proliferation-sensitive nuclear phosphoprotein "dividin" is synthesized almost exclusively during S phase of the cell cycle in human AMA cells.
MedLine Citation:
PMID:  3464947     Owner:  NLM     Status:  MEDLINE    
Studies of the polypeptides synthesized by normal and transformed human cultured cells under a variety of physiological conditions have revealed a basic 54-kDa protein NEPHGE 10a, whose rate of synthesis is sensitive to changes in the rate of cell proliferation. This nuclear phosphoprotein, which we have termed "dividin" (present only in populations of cells committed to divide), is synthesized almost exclusively during the S phase of the cell cycle of transformed human amnion cells (AMA). Dividin synthesis is first detected late in G1 near the G1/S transition border, reaches a maximum late in S phase, and declines thereafter. As expected for an S phase-specific protein, no detectable synthesis of dividin was observed in growth-arrested normal human cultured cells of epithelial and fibroblast origin. These findings suggest a role for this protein in events leading to DNA replication and cell division.
J E Celis; S Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  83     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-05     Completed Date:  1986-12-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8187-90     Citation Subset:  IM    
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MeSH Terms
Amnion / metabolism
Cell Division / drug effects*
Cell Line
Cell Transformation, Neoplastic / metabolism
DNA Replication
Nucleoproteins / biosynthesis*
Phosphoproteins / biosynthesis*
Reg. No./Substance:
0/Nucleoproteins; 0/Phosphoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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