| Proliferation of renal mesangial cells induced by very low density lipoprotein is mediated by p42/44 mitogen activated protein kinase. | |
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MedLine Citation:
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PMID: 21034657 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The plasma concentration of very low density lipoprotein (VLDL) is negatively correlated to renal function in glomerular diseases. Effects of VLDL on renal function have been partially attributed to the proliferation of mesangial cells. This study examined the potential role of the p42/44 mitogen activated protein kinase (MAPK) in mesangial cell proliferation induced by VLDL. METHODS: Mesangial cells were treated with VLDL at different concentrations or for different time. The cell cycle of the mesangial cells was analyzed by XTT assay and flow-cytometry; MAPK activity was also assayed. In some experiments, cells were treated with VLDL together with or without 0.1 µmol/L PD 98059. RESULTS: Ten to 500 µg/ml VLDL stimulated the proliferation of mesangial cells cultured in vitro in a concentration-dependent manner. The effect was associated with an increase in p42/44 MAPK activity. Increased proliferation of mesangial cells by VLDL was significantly attenuated by PD98059, a specific p42/44 MAPK inhibitor. CONCLUSION: These results indicate that the p42/44 MAPK pathway is an important regulator of mesangial cell proliferation and of renal functions. |
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Authors:
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Guo-qing Yu; Wei-jie Yuan; Ruo-lan Cui; Peng Fu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 123 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 2710-3 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Dongfang Hospital, Fuzhou, Fujian 350025, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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