Document Detail


Proliferation of protease-enriched mast cells in sarcoptic skin lesions of raccoon dogs.
MedLine Citation:
PMID:  15144797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skin sites, tongue, lung, liver, jejunum and rectum from two raccoon dogs with Sarcoptes scabiei infestation and five normal (control) raccoon dogs were examined in terms of the distribution, proteoglycan properties and protease activity of mast cells. Infestation with S. scabiei caused a significant increase in the number of dermal mast cells. While the number of mast cells (average +/- standard deviation) in specimens of skin from the dorsum, dorsal neck, dorsal hind foot and dorsal fore foot was 40.0 +/- 19.8/mm2 in control animals, it was 236.1 +/- 58.9/mm2 in the skin of mange-infested animals. Histochemical analysis revealed the glycosaminoglycan, heparin, within the mast cells of all organs examined in both control and affected animals. Enzyme-histochemical detection of serine proteases demonstrated an increase in mast-cell-specific protease activity (i.e., chymase and tryptase) in the skin of infested animals. The percentage of mast cells demonstrating chymase activity was 53.0 +/- 27.4% in control animals and 73.8 +/- 19.4% in mite-infested animals. The corresponding results for tryptase activity were 53.5 +/- 25.2% and 89.4 +/- 9.8%. Increases in mast cell chymase or tryptase activity, or both, were also observed within other organs of the infected animals, but the total number of mast cells found at such sites (with the exception of liver and ventrolateral pinna) did not differ from those of control animals.
Authors:
D Noviana; D W Harjanti; Y Otsuka; Y Horii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  131     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-05-17     Completed Date:  2004-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  28-37     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Elsevier Ltd.
Affiliation:
Department of Veterinary Teaching Hospital and Internal Medicine, Faculty of Agriculture, University of Miyazaki, Gakuen-kibanadai Nishi 1-1, Miyazaki 889-2192, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chymases
Heparin / metabolism
Immunohistochemistry
Male
Mast Cells / cytology,  enzymology*
Raccoon Dogs
Sarcoptes scabiei
Scabies / immunology,  pathology*,  veterinary*
Serine Endopeptidases / metabolism*
Skin / cytology,  immunology*
Tryptases
Chemical
Reg. No./Substance:
9005-49-6/Heparin; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.39/Chymases; EC 3.4.21.59/Tryptases

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