Document Detail


Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid beta-oxidation.
MedLine Citation:
PMID:  2338145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Marked proliferation of rat hepatic peroxisomes is observed after treatment with a new potent hypolipidemic drug BM 15766, as well as after bezafibrate. Whereas the relative specific activity of the peroxisomal fatty acid beta-oxidation system is not affected by BM 15766 it is significantly increased after bezafibrate. This is also confirmed by immunoblot analysis of individual beta-oxidation enzymes in highly purified peroxisome fractions. These observations suggest that peroxisome proliferation and the induction of the fatty acid beta-oxidation are regulated separately.
Authors:
E Baumgart; A Völkl; J Pill; H D Fahimi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  264     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-20     Completed Date:  1990-06-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cell Biology II, University of Heidelberg, FRG.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antilipemic Agents / pharmacology*
Bezafibrate / pharmacology*
Carnitine O-Acetyltransferase / metabolism
Catalase / metabolism
Fatty Acids / metabolism*
Liver / drug effects,  metabolism,  ultrastructure*
Male
Microbodies / drug effects,  metabolism,  ultrastructure*
Oxidation-Reduction
Piperazines / pharmacology*
Rats
Rats, Inbred Strains
Reference Values
Sterols / blood
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Fatty Acids; 0/Piperazines; 0/Sterols; 0/Triglycerides; 41859-67-0/Bezafibrate; 86621-92-3/BM 15766; EC 1.11.1.6/Catalase; EC 2.3.1.7/Carnitine O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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