Document Detail

Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid beta-oxidation.
MedLine Citation:
PMID:  2338145     Owner:  NLM     Status:  MEDLINE    
Marked proliferation of rat hepatic peroxisomes is observed after treatment with a new potent hypolipidemic drug BM 15766, as well as after bezafibrate. Whereas the relative specific activity of the peroxisomal fatty acid beta-oxidation system is not affected by BM 15766 it is significantly increased after bezafibrate. This is also confirmed by immunoblot analysis of individual beta-oxidation enzymes in highly purified peroxisome fractions. These observations suggest that peroxisome proliferation and the induction of the fatty acid beta-oxidation are regulated separately.
E Baumgart; A Völkl; J Pill; H D Fahimi
Related Documents :
3119765 - Influence of 2(3-methyl-cinnamyl-hydrazono)-propionate on glucose and palmitate oxidati...
17404155 - Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine p...
1062135 - Rate-limiting steps of carbohydrate and fatty acid metabolism in ischemic hearts.
2002205 - Carnitine, valproate, and toxicity.
1495015 - Preparation and structure-activity relationships of simplified analogues of the antifun...
133645 - Analgesic and anti-inflammatory activity of 6-chloro-alpha-methyl-carbazole-2-acetic ac...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  264     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-20     Completed Date:  1990-06-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
Department of Anatomy and Cell Biology II, University of Heidelberg, FRG.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antilipemic Agents / pharmacology*
Bezafibrate / pharmacology*
Carnitine O-Acetyltransferase / metabolism
Catalase / metabolism
Fatty Acids / metabolism*
Liver / drug effects,  metabolism,  ultrastructure*
Microbodies / drug effects,  metabolism,  ultrastructure*
Piperazines / pharmacology*
Rats, Inbred Strains
Reference Values
Sterols / blood
Triglycerides / blood
Reg. No./Substance:
0/Antilipemic Agents; 0/Fatty Acids; 0/Piperazines; 0/Sterols; 0/Triglycerides; 41859-67-0/Bezafibrate; 86621-92-3/BM 15766; EC; EC O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits...
Next Document:  A distinct thimet peptidase from rat liver mitochondria.