| Proliferation of peroxisomes without simultaneous induction of the peroxisomal fatty acid beta-oxidation. | |
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MedLine Citation:
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PMID: 2338145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Marked proliferation of rat hepatic peroxisomes is observed after treatment with a new potent hypolipidemic drug BM 15766, as well as after bezafibrate. Whereas the relative specific activity of the peroxisomal fatty acid beta-oxidation system is not affected by BM 15766 it is significantly increased after bezafibrate. This is also confirmed by immunoblot analysis of individual beta-oxidation enzymes in highly purified peroxisome fractions. These observations suggest that peroxisome proliferation and the induction of the fatty acid beta-oxidation are regulated separately. |
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Authors:
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E Baumgart; A Völkl; J Pill; H D Fahimi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FEBS letters Volume: 264 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-06-20 Completed Date: 1990-06-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 5-9 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology II, University of Heidelberg, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology* Bezafibrate / pharmacology* Carnitine O-Acetyltransferase / metabolism Catalase / metabolism Fatty Acids / metabolism* Liver / drug effects, metabolism, ultrastructure* Male Microbodies / drug effects, metabolism, ultrastructure* Oxidation-Reduction Piperazines / pharmacology* Rats Rats, Inbred Strains Reference Values Sterols / blood Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Fatty Acids; 0/Piperazines; 0/Sterols; 0/Triglycerides; 41859-67-0/Bezafibrate; 86621-92-3/BM 15766; EC 1.11.1.6/Catalase; EC 2.3.1.7/Carnitine O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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