Document Detail

Proliferation of normal breast epithelial cells as shown by in vivo labeling with bromodeoxyuridine.
MedLine Citation:
PMID:  2053594     Owner:  NLM     Status:  MEDLINE    
The proliferative activity of normal acinar and ductal breast epithelial cells was studied by in vivo labeling with 5-bromodeoxyuridine (BrdUrd) in 26 cases with concurrent breast carcinoma. The BrdUrd-labeled cells were recognized in histologic sections of paraffin-embedded tissue, using an anti-BrdUrd antibody and an immunoperoxidase reaction. The percentage of BrdUrd-labeled cells showed great variability for both acinar (0% to 2.66%; mean, 0.70%; standard deviation [SD], 0.80%) and ductal cells (0% to 1.99%; mean, 0.51%; SD, 0.57%). The fraction of proliferating epithelial cells declined with the age of the patients and was significantly higher in premenopausal women (1.16% +/- 0.85% for acinar and 0.94% +/- 0.60% for ductal cells) as compared with the postmenopausal women (0.27% +/- 0.46% for acinar and 0.17% +/- 0.22% for ductal cells), P less than 0.01 for acinar and P less than 0.001 for ductal cells, respectively. In some patients, great variability in distribution of proliferating acinar and ductal cells among different lobules and ducts was observed. No difference was found in the number of proliferating acinar and ductal cells situated near or far from their corresponding tumors. No correlation was seen between cell proliferation of normal acinar or ductal cells and cell proliferation of the respective tumors.
K Christov; K L Chew; B M Ljung; F M Waldman; L A Duarte; W H Goodson; H S Smith; B H Mayall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of pathology     Volume:  138     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-25     Completed Date:  1991-07-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1371-7     Citation Subset:  AIM; IM    
Department of Laboratory Medicine, University of California, San Francisco 94143-0808.
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MeSH Terms
Aging / metabolism
Breast / cytology*,  ultrastructure
Breast Neoplasms / pathology
Bromodeoxyuridine / diagnostic use*
Cell Division
Cell Nucleus / ultrastructure
Epithelial Cells
Immunoenzyme Techniques
Menstrual Cycle / physiology
Middle Aged
Reference Values
Tissue Distribution
Grant Support
P01-44768//PHS HHS
Reg. No./Substance:

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