Document Detail


Proliferation and metabolic significance of peroxisomes in Candida boidinii during growth on D-alanine or oleic acid as the sole carbon source.
MedLine Citation:
PMID:  2339955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied the induction of peroxisomes in the methylotrophic yeast Candida boidinii by D-alanine and oleic acid. The organism was able to utilize each of these compounds as the sole carbon source and grew with growth rates of mu = 0.20 h-1 (on D-alanine) or mu = 0.43 h-1 (on oleic acid). Growth was associated with the development of many peroxisomes in the cells. On D-alanine a cluster of tightly interwoven organelles was observed which made up 6.3% of the cytoplasmic volume and were characterized by the presence of D-amino acid oxidase and catalase. On oleic acid rounded to elongated peroxisomes were dominant which were scattered throughout the cytoplasm. These organelles contained increased levels of beta-oxidation enzymes; their relative volume fraction amounted 12.8% of the cytoplasmic volume.
Authors:
G J Sulter; H R Waterham; J M Goodman; M Veenhuis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of microbiology     Volume:  153     ISSN:  0302-8933     ISO Abbreviation:  Arch. Microbiol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-06-19     Completed Date:  1990-06-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410427     Medline TA:  Arch Microbiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  485-9     Citation Subset:  IM    
Affiliation:
Department of Microbiology, University of Groningen, Haren, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Alanine / metabolism*
Candida / growth & development,  metabolism,  ultrastructure*
Cell Fractionation
Culture Media
Microbodies / enzymology,  metabolism*,  ultrastructure
Microscopy, Electron
Oleic Acid
Oleic Acids / metabolism*
Oxidoreductases / metabolism
Grant Support
ID/Acronym/Agency:
GM31859/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Culture Media; 0/Oleic Acids; 112-80-1/Oleic Acid; 56-41-7/Alanine; EC 1.-/Oxidoreductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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