Document Detail

Proliferation hemangiomas formation through dual mechanism of vascular endothelial growth factor mediated endothelial progenitor cells proliferation and mobilization through matrix metalloproteinases 9.
MedLine Citation:
PMID:  17888584     Owner:  NLM     Status:  MEDLINE    
Infantile hemangioma is the most common tumor of infancy and the mechanism leading to proliferation hemangiomas formation is poorly understood and currently no successful treatment modality exists. We hypothesize that EPCs formed during proliferation hemangiomas, as the result of vascular endothelial growth factor (VEGF) stimulation through MMP9, play the major role in the control of cell proliferation and capillary-like vessels production. Accepting the hypothesis to be correct, a therapy that inhibits EPC mobilization and proliferation can be used to prevent the proliferation hemangiomas formation. Current therapies are only partially effective and safe because they could not eliminate all the relative factors of proliferation hemangiomas formation at all, such as: EPCs in the peripheral blood, and at the same time inducing death (apoptosis and necrosis) of other normal cells. A more efficient prevention of proliferation hemangiomas could be achieved using specific drugs or biologic methods that inhibit EPC mobilization and proliferation. Therapy based on gene therapy, capable to specifically inhibit VEGF and MMP9 expression in gene level, can be possibly effective.
Guo-You Zhang; Cheng-Gang Yi; Xuan Li; Zi-Qian Liang; Run-Xiu Wang; Da-En Liu; Li-Ming Zhang; Cheng-Yue Meng; Shu-Zhong Guo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-20
Journal Detail:
Title:  Medical hypotheses     Volume:  70     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  815-8     Citation Subset:  IM    
Department of Burn and Plastic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
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MeSH Terms
Capillaries / metabolism
Cell Proliferation
Endothelial Cells / cytology*
Flow Cytometry / methods
Gene Therapy / methods
Hemangioma / etiology*,  pathology*
Matrix Metalloproteinase 9 / metabolism*
Models, Biological
Models, Theoretical
Neovascularization, Physiologic
Stem Cells / cytology*
Vascular Endothelial Growth Factor A / metabolism*
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; EC Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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