Document Detail


Proliferation of germ cells during gonadal sex differentiation in medaka: Insights from germ cell-depleted mutant zenzai.
MedLine Citation:
PMID:  17825277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The proliferation of germ cells becomes sexually dimorphic during gonadal sex differentiation, although the underlying dynamics of this are not well understood in vertebrates. By tracing GFP-labeled germ cells in vivo and analyzing the germ cell-depleted mutant, zenzai, we show that the proliferation and differentiation of germ cells are regulated in a sexually dimorphic manner in the teleost fish medaka. In the undifferentiated gonads, germ cells resume proliferation by slow intermittent division (type I), producing isolated daughter cells. While germ cells in the male gonads continue this mode of proliferation, some germ cell fractions in the female gonads initiate two to four rounds of continuous division (type II), forming cysts of four, eight, or sixteen cells, which subsequently enter meiosis synchronously. Thus, female germ cells become differentiated much earlier than do male germ cells. In the zenzai mutant, a defect in slow intermittent division eventually leads to the depletion of germ cells in the adult gonads in both sexes, despite the fact that cyst-forming division is unaffected. This argues that slow intermittent division is essential for the maintenance of germ cells. The proliferation and differentiation of germ cells are thus important components of gonadal sex differentiation in vertebrates.
Authors:
Daisuke Saito; Chikako Morinaga; Yumiko Aoki; Shuhei Nakamura; Hiroshi Mitani; Makoto Furutani-Seiki; Hisato Kondoh; Minoru Tanaka
Related Documents :
2465117 - Analysis of germ line development in the chick embryo using an anti-mouse ec cell antib...
18088417 - Conserved and divergent patterns of expression of dazl, vasa and oct4 in the germ cells...
1061157 - Totipotency and normal differentiation of single teratocarcinoma cells cloned by inject...
17286597 - Differentiation of liver cells from human primordial germ cell-derived progenitors.
3698077 - Kinetics of cell replacement in the stratum granulosum of mouse tongue epithelium.
3026397 - Activation of collagenase production in a rat macrophage-like cell line.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-07
Journal Detail:
Title:  Developmental biology     Volume:  310     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-02     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  280-90     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Higashiyama, Okazaki, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Proliferation
Female
Germ Cells / cytology*,  physiology,  ultrastructure
Male
Mutation
Oryzias / embryology,  genetics,  physiology*
Sex Differentiation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Preschoolers' use of spatiotemporal history, appearance, and proper name in determining individual i...
Next Document:  Cyclin E2 is required for embryogenesis in Xenopus laevis.