Document Detail


Proliferation of endocrine cells in the rat stomach caused by drug-induced achlorhydria.
MedLine Citation:
PMID:  2044929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Time-related changes of serum gastrin levels, gastrin cell, and enterochromaffinlike cell densities, and proliferation kinetics of these cells have been examined in rats during treatment with the substituted benzimidazole BY 308 over a period of 73 days. Serum gastrin levels increased very rapidly from 74 +/- 6 pg/mL (controls) to 438 +/- 31 pg/mL (day 1) and 727 +/- 68 pg/mL (day 4). Thereafter, a steady increase was observed until day 70 (2097 +/- 208 pg/mL). Enterochromaffinlike cell density was unchanged until day 10, but then increased progressively without reaching a plateau (144% above control on day 73). The labeling index of these cells was enhanced shortly after drug application and remained on a constant elevated level from day 14 to day 73 (about 10-fold to 12-fold above controls from day 14 to day 70). The number of gastrin cells increased rapidly within the first week and reached a plateau after 17 days (96% increase above controls). In contrast to enterochromaffinlike cells, the labeling index did not change immediately but increased on day 7 by 37% and returned beneath control values after day 28. The results suggest that in drug-induced achlorhydria, the progressive increase of enterochromaffinlike cells is explained by an enhanced mitosis, whereas other factors in addition to proliferation are responsible for the augmentation of gastrin cells.
Authors:
R Eissele; B Rosskopf; H Koop; G Adler; R Arnold
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  101     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-07-12     Completed Date:  1991-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Philipps University, Marburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
2-Pyridinylmethylsulfinylbenzimidazoles
Achlorhydria / chemically induced,  pathology*
Animals
Cell Count
Enterochromaffin Cells / drug effects,  pathology*
Female
Gastrins / blood*
Hyperplasia
Mitotic Index / drug effects
Omeprazole / analogs & derivatives,  pharmacology
Rats
Rats, Inbred Strains
Regression Analysis
Stomach / drug effects,  metabolism,  pathology*
Time Factors
Chemical
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Gastrins; 73590-58-6/Omeprazole; 86604-69-5/B 823-08

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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