| Proliferation effect of neural stem cell of ginsenoside Rg1 in vitro | |
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MedLine Citation:
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PMID: 19459308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the proliferation effect of neural stem cells (NSCs) of ginsenoside Rg1 in vitro. METHOD: NSCs from the embryonic rat (E14) were isolated, 10 mg x L(-1) BrdU were added in the medium. The NSCs were incubated together with 1, 10 micromol x L(-1) ginsenoside Rg1 for 48 hours, control group were setup. Then BrdU positive cell number were detected and counted by fluorescence microscop. The Hes1 and Mash1 mRNA expression were detected by real-time RT-PCR. RESULT: The number of BrdU positive cells in 10 micromol x L(-1) ginsenoside Rg1 group was increased significantly compared with the control group (40.5 +/- 10.9 vs 26.2 +/- 6.0, P < 0.01), and the Hes1 mRNA expression were increased significantly (1.00 +/- 0.11) vs (1.28 +/- 0.14), P < 0.05. CONCLUSION: ginsenoside Rg1 can promote the proliferation of neural stem cells in vitro, and this effect may be induced by the up-regulation Hes1 expression. |
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Authors:
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Pengwei Zhuang; Yanjun Zhang; Tan Pang |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Volume: 34 ISSN: 1001-5302 ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-05-22 Completed Date: 2009-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913656 Medline TA: Zhongguo Zhong Yao Za Zhi Country: China |
Other Details:
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Languages: chi Pagination: 443-6 Citation Subset: IM |
Affiliation:
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Tianjin University of Traditional Chinese Medicine, Tianjin Laboratory of Chinese Medience Pharmacology, Tianjin 300193, China. zhuangpengwei@163.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation / drug effects* Ginsenosides / pharmacology* Multipotent Stem Cells / drug effects, physiology Neurons / drug effects*, physiology Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Ginsenosides; 22427-39-0/ginsenoside Rg1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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