Document Detail

Proliferation and distribution of myoepithelial cells during atrophy of the rat sublingual gland.
MedLine Citation:
PMID:  12542831     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The present study was aimed to determine the proliferation and distribution of myoepithelial cells during atrophy of rat sublingual glands. METHODS: The excretory duct of the right sublingual gland of rats was doubly ligated with metal clips to induce atrophy in the gland. The atrophic sublingual glands were taken from 1 to 28 days after duct ligation and examined with single immunohistochemistry for actin as a marker of myoepithelial cells and with immunohistochemical double staining for actin and proliferating cell nuclear antigen (PCNA) as a marker of proliferating cells. RESULTS: In unligated sublingual glands, myoepithelial cells embraced acini and intercalated ducts, but not striated and interlobular excretory ducts. In the early stages of atrophy, myoepithelial cells surrounded small ducts but not large ones. However, in the later stages of atrophy, myoepithelial cells were also observed at the periphery of the large ducts. The immunohistochemical double staining showed that there were PCNA-positive myoepithelial cells in the normal as well as in the atrophic sublingual glands. However, the PCNA labeling indices of myoepithelial cells were low in the unligated and atrophic sublingual glands, and there were no statistically significant differences in these labeling indices. CONCLUSION: The observations suggest that the distribution of myoepithelial cells change during atrophy of rat sublingual glands and that myoepithelial cells have low proliferative activity in both the normal and atrophic condition of rat sublingual glands.
S Takahashi; K Shinzato; T Domon; T Yamamoto; M Wakita
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  32     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-24     Completed Date:  2003-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  90-4     Citation Subset:  D; IM    
Department of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo,
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MeSH Terms
Actins / analysis
Analysis of Variance
Cell Division
Epithelial Cells / cytology,  pathology*,  physiology
Immunoenzyme Techniques
Muscle, Smooth / cytology
Proliferating Cell Nuclear Antigen / analysis
Rats, Wistar
Sublingual Gland / chemistry,  cytology*,  pathology*
Reg. No./Substance:
0/Actins; 0/Proliferating Cell Nuclear Antigen

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