Document Detail


Proliferation and differentiation of the small intestinal epithelium: from Petri dish to bedside.
MedLine Citation:
PMID:  7599348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The small intestinal epithelium is a continuously renewing cell system in which two main compartments can be defined: the crypt compartment and the villus compartment. The crypt compartment houses the proliferative cells (stem cells) that give birth to the four types of differentiated enterocytes (absorptive enterocytes, goblet cells, enteroendocrine cells, Paneth cells) that, with the exception of Paneth cells, populate the villus compartment. Enterocyte proliferation, differentiation and migration are regulated by a complex network of cell-cell and cell-matrix information, and modulated by growth factors, luminal factors and, possibly, hormones. The intimate mechanisms underlying the fascinating life of the enterocytes are the object of intensive investigation although insights have come from studies "in vitro" and in transgenic animals. The enormous proliferative potential makes the small bowel an extremely plastic organ, able to adapt to various injuries and adverse conditions and to completely recover even from extensive damage. Knowledge of the biologic mechanisms of adaptation has begun to affect therapeutic approaches to a number of intestinal diseases and the future will see a significant advancement in their management. More important, understanding the molecular mechanisms regulating the perfect equilibrium between proliferation and differentiation of the intestinal enterocytes will eventually help disclose the dark side of cancer.
Authors:
B Daniele; L D'Agostino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Italian journal of gastroenterology     Volume:  26     ISSN:  0392-0623     ISO Abbreviation:  Ital J Gastroenterol     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000544     Medline TA:  Ital J Gastroenterol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  459-70     Citation Subset:  IM    
Affiliation:
Divisione di Oncologia Medica B, Facoltà di Medicina, Università Federico II, Napoli, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle / physiology
Cell Differentiation / physiology
Epithelium / growth & development
Growth Substances / metabolism
Hormones / metabolism
Humans
Intestinal Mucosa / cytology,  growth & development*,  metabolism
Intestine, Small / cytology,  growth & development*,  metabolism
Chemical
Reg. No./Substance:
0/Growth Substances; 0/Hormones

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