Document Detail

Proliferation of colonic lymphocytes in response to inflammatory cytokines is lower in mice fed fish oil than in mice fed corn oil.
MedLine Citation:
PMID:  10680589     Owner:  NLM     Status:  MEDLINE    
The literature supports an association of chronic inflammation with the development of tumors. The colon contains a specialized lymphocyte population that may influence various stages of colon carcinogenesis. Dietary factors are known to affect both inflammation and tumor development in this tissue. Diets high in n-6 fatty acids are considered to be proinflammatory and tumor-promoting whereas n-3 fatty acids are not. This study examined the proliferative response of colonic lymphocytes (CL) from BALB/c mice fed a diet high in either corn oil or menhaden oil when cultured in the presence of proinflammatory cytokines. CL were isolated from mice fed one of the experimental diets and cultured in the presence of anti-CD2, IL-1beta, IL-2, or TNF-alpha. Proliferation of CL in culture was measured by BrdU incorporation. CL from mice fed the high n-3 diet showed lower rates of proliferation following exposure to the inflammatory cytokines than CL from mice fed the high n-6 diet. CL from the high n-3 group showed the same proliferative potential as those from the n-6 diet group following exposure to a combination of anti-CD2 and TNF. Results from this study indicate that diets high in n-3 fatty acids slow the inflammatory response in the colon as compared to diets high in n-6 fatty acids. The n-3 lipids do not appear to compromise overall immune potential, however.
C N Kuratko
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  148     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-25     Completed Date:  2000-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
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MeSH Terms
Antibodies / immunology,  pharmacology
Antigens, CD2 / immunology,  physiology
Body Weight / drug effects
Carcinogens / administration & dosage,  chemistry,  pharmacology
Cell Division / drug effects
Cells, Cultured
Colon / cytology,  drug effects,  immunology*
Corn Oil / administration & dosage,  chemistry,  pharmacology*
Cytokines / pharmacology*
Fish Oils / administration & dosage,  chemistry,  pharmacology*
Interleukins / pharmacology
Lymphocytes / cytology*,  drug effects*,  immunology
Mice, Inbred BALB C
Mitogens / pharmacology
Tumor Necrosis Factor-alpha / pharmacology
Reg. No./Substance:
0/Antibodies; 0/Antigens, CD2; 0/Carcinogens; 0/Cytokines; 0/Fish Oils; 0/Interleukins; 0/Mitogens; 0/Tumor Necrosis Factor-alpha; 8001-30-7/Corn Oil; 8002-50-4/Menhaden oil

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