Document Detail

Proliferation of C6 glioma cells is blunted by the increase in gap junction communication caused by tolbutamide.
MedLine Citation:
PMID:  11741589     Owner:  NLM     Status:  MEDLINE    
We have previously reported that tolbutamide prevents the inhibition of gap junction communication in astrocytes. Here, we show that tolbutamide increases gap junction communication and connexin 43 expression in poorly coupled C6 glioma cells. The increase in communication is concurrent with the inhibition of the rate of proliferation due to a block of the progression of C6 glioma cells through the S phase of the cell cycle. The effects of tolbutamide were quantitatively similar to that found after the elevation of intracellular cAMP. Furthermore, the effects of tolbutamide and cAMP were additive. The possible beneficial effect of tolbutamide on gene therapy for gliomas is discussed.
R Sánchez-Alvarez; A Tabernero; L I Sánchez-Abarca; A Orfao; C Giaume; J M Medina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  509     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-19     Completed Date:  2002-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  202-6     Citation Subset:  IM    
Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Salamanca, Edificio Departamental, Pza Doctores de la Reina s/n, 37007 Salamanca, Spain.
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MeSH Terms
Cell Communication / drug effects
Cell Division / drug effects
Cell Membrane Permeability / drug effects
Connexin 43 / biosynthesis
Cyclic AMP / metabolism
Gap Junctions / drug effects*
Glioma / drug therapy*
S Phase / drug effects
Tolbutamide / pharmacology*
Reg. No./Substance:
0/Connexin 43; 60-92-4/Cyclic AMP; 64-77-7/Tolbutamide

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