| Proliferation and Apoptosis of Peripheral Blood Mononuclear Cells in Patients with Oral Lichen Planus. | |
| | |
MedLine Citation:
|
PMID: 23135214 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Oral lichen planus (OLP) is generally accepted to be a T cell-mediated chronic inflammatory disease with an unclear pathogenesis. There have been numerous studies on the proliferation and apoptosis of T cells in situ. In contrast, research on the proliferation and apoptosis of peripheral blood mononuclear cells (PBMCs) in patients with OLP is rare. The aim of the present study was to investigate the proliferation and apoptosis of PBMCs in patients with OLP. PBMCs were isolated from 20 patients with reticular OLP, 20 patients with atrophic-erosive OLP, and 20 healthy volunteers. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2,5-tetrazolium bromide assays were performed to investigate the proliferation of PBMCs, and caspase-3 colorimetric assays were performed to investigate the apoptosis of PBMCs. The proliferation rate of PBMCs in atrophic-erosive OLP subjects was significantly higher than that in both healthy (P < 0.05) and reticular OLP (P < 0.05) subjects. In contrast, the proliferation rate of PBMCs in reticular OLP subjects was significantly lower than that in healthy subjects (P < 0.05). The apoptosis rates of PBMCs in OLP subjects (P < 0.05) and atrophic-erosive OLP subjects (P < 0.05) were significantly lower than the apoptosis rate in the healthy group. Our findings reinforce the view that T cell-mediated immune responses play a critical role in the pathogenesis of OLP. It can reasonably be concluded that these abnormalities are linked to the presence of inflammatory infiltrates. |
| | |
Authors:
|
Jing Shan; Jiang-Min Ma; Ran Wang; Qing-Lan Liu; Yuan Fan |
Related Documents
:
|
23196804 - Hydrogen sulfide as an oxygen sensor. 23202444 - Mirna profiles of monocyte-lineage cells are consistent with complicated roles in hiv-1... 23420884 - β2-adrenoreceptor agonist inhibits antigen cross-presentation by dendritic cells. 20093144 - L-carnitine attenuates oxidant injury in hk-2 cells via ros-mitochondria pathway. 22023084 - Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal... 11727524 - Hsppc-96: a personalised cancer vaccine. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-8 |
Journal Detail:
|
Title: Inflammation Volume: - ISSN: 1573-2576 ISO Abbreviation: Inflammation Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600105 Medline TA: Inflammation Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Institute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, Jiangsu, 210029, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Strategies to Increase Flap Survival in Nasal Reconstruction in Patients With Deep Panfacial Burns.
Next Document: Towards a More Cloud-Friendly Medical Imaging Applications Architecture: A Modest Proposal.