Document Detail

Proliferating trichilemmal tumor of the nose.
Jump to Full Text
MedLine Citation:
PMID:  23197215     Owner:  NLM     Status:  In-Data-Review    
Proliferating trichilemmal tumor is a rare tumor originating in the external root sheath, that is usually found in the scalp of middle-aged or elderly females. Its histologic appearance may not correlate with its clinical behavior. In addition, there are no guidelines available for the treatment of these tumors, making its management a challenge for physicians. We report the case of a 53 year-old woman with a proliferating trichilemmal tumor on her nose, which is a very uncommon location for these lesions.
Aristóteles Rosmaninho; Mónica Caetano; Ana Oliveira; Teresa Pinto de Almeida; Manuela Selores; Rosário Alves
Related Documents :
25222555 - Identification of apolipoprotein c-i as a potential wilms' tumor marker after excluding...
15690295 - Morphometric analysis of mouse tumor nuclei subjected to photodynamic therapy.
7599385 - Unilateral localized basaliomatosis: treatment with topical photodynamic therapy after ...
23084585 - Desmoplastic spindle cell thymomas: a clinicopathologic and immunohistochemical study o...
6928335 - Studies of the distribution of abnormal cells in cytologic preparations. i. making the ...
12451785 - Development of a cryo-device for minimal-invasive application under mri-control.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anais brasileiros de dermatologia     Volume:  87     ISSN:  1806-4841     ISO Abbreviation:  An Bras Dermatol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0067662     Medline TA:  An Bras Dermatol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  914-6     Citation Subset:  IM    
Dermatovenereology Service, Hospital Santo António, Porto Hospital Center, Porto, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): An Bras Dermatol
Journal ID (iso-abbrev): An Bras Dermatol
Journal ID (publisher-id): An. bras. dermatol.
ISSN: 0365-0596
ISSN: 1806-4841
Publisher: Sociedade Brasileira de Dermatologia
Article Information
Download PDF©2012 by Anais Brasileiros de Dermatologia
Received Day: 07 Month: 9 Year: 2011
Accepted Day: 08 Month: 11 Year: 2011
Print publication date: Season: Nov-Dec Year: 2012
Volume: 87 Issue: 6
First Page: 914 Last Page: 916
PubMed Id: 23197215
ID: 3699925
DOI: 10.1590/S0365-05962012000600017

Proliferating trichilemmal tumor of the nose*
Aristóteles Rosmaninho1
Mónica Caetano2
Ana Oliveira1
Teresa Pinto de Almeida1
Manuela Selores3
Rosário Alves2
1MD - Intern of Dermatovenereology - Dermatovenereology Service of the Porto Hospital Center - Hospital Santo António (EPE-HSA) - Porto, Portugal
2MD - Hospital Assistant of Dermatovenereology - Dermatovenereology Service of the Porto Hospital Center - Hospital Santo António (EPE-HSA) - Porto, Portugal
3MD - Director of the Dermatovenereology Service of the Porto Hospital Center - Hospital Santo António (EPE-HSA) - Porto, Portugal
Correspondence: Mailing address: Aristóteles Rosmaninho, Edifício das Consultas Externas, Rua D. Manuel II, s/nº, 4099-001 Porto, Portugal, E-mail:


Proliferating trichilemmal tumor (PTT) is a rare, usually benign tumor of external root sheath derivation and have been reported with varying nomenclature, e.g., invasive pilomatrixioma, proliferating epidermoid cyst, trichoclamydocarcinoma, pilar tumor. 1,2 They are slow growing lobular tumors, whose histologic hallmark is the presence of trichilemmal keratinization. 3 Tumors with an invasive growth pattern or cytologic atypia have an unpredictable course and may be locally aggressive or metastasize. Thus, it has been suggested that even the classical PTT should be considered as carcinoma. 4


A 53-year-old woman presented with a one-year history of a gradually enlarging lesion on the nose that was otherwise asymptomatic. The lesion had evidently been growing in the last 3 months. She denied trauma or insect bite at this location. Her medical history was unremarkable. On physical examination a localized, non-painful skin colored nodule with a smooth surface, soft consistency, measuring 0.5 x 0.5 cm (Figure 1) was observed on the nose. There were no palpable adenomegalies. Total lesion surgical excision with a 0.5 cm margin of normal tissue was performed. Hematoxylin-eosin stain revealed a multilobular, noncapsulated tumor occupying all the dermis (Figure 2A). Lobules were formed by peripheral palisading of small basaloid cells, differentiating towards large keratinocytes with ample eosinophilic cytoplasm and abrupt keratinization without a granular layer (Figure 2B). Areas of calcification with cholesterol crystals were observed within the compact eosinophilic keratin (Figure 3A). The tumor cells showed moderate nuclear atypia and scarce mitoses (Figure 3B). This was consistent with PTT. Wide surgical excision with a 1 cm margin of normal tissue was performed and no relapse was observed during the 8-month period of follow-up.


PTT is more frequent in middle-aged women and more than 90% of the lesions are localized on the scalp but the face, trunk, back, wrist and vulva can also be affected.1,2,5 Etiopathogenesis remains unknown but in most cases it appears to developed within the wall of a pre-existenting pilar cyst as complication of trauma and inflammation. 6 It has also been reported to develop in nevus sebaceous and human papillomavirus has also been implicated. 7 Nevertheless, PTT can occur de novo, as in our report. 6 Histologically it occurs on a morphologic continuum, resembling the pilar cyst on one end of the spectrum and with features of malignant neoplasms on the other end. 6 In addition to typical pilar cyst characteristics, extensive keratinocyte proliferation, variable cytologic atypia and mitotic activity are present. Brownstein et al concluded that the most characteristic feature of PTTs was trichilemmal keratinization. 6 It is accepted that cytologic atypia may be present in PTT that ultimately have a benign behaviour. However, the malignant variant also shows cytologic atypia and mitotic activity. This issue remains controversial since tumors with little or no cytologic atypia may be aggressive, showing that their histologic appearance does not necessarily correlate with their biological behaviour. 4 Therefore, as proposed by some authors, it is advisable to consider PTTs with those features as being at high risk of malignant transformation. 2 It has been proposed that a nonscalp location, recent rapid growth, size larger than 5 cm, infiltrative growth and important cytologic atypia with mitotic activity should be regarded as malignancy. 2 Infiltrating tumors with marked atypia and pleomorphism may be histologically mistaken as squamous cell carcinoma (SCC) and trichilemmal carcinoma (TC). Trichilemmal-type keratinization, calcification, eosinophilic hyaline membrane surrounding the tumor, ordinary trichilemmal cyst, lack of a precursory epidermal lesion are all indicators of PTT rather than SCC. 6 It is important to distinguish TC from the malignant variant of PTT, because the first does not have metastatic potential. TC is centered around a pilosebaceous unit and is composed of cytologically atypical, glycogen-containing or pale clear cell with basilar or full-thickness interfollicular epidermal spread; there is always a connection to the epidermis. 8 Due to its rarity there are no guidelines available for the management of these tumors. However, complete local excision with long-term follow-up is still the standard treatment. 9 A one-centimeter margin of normal tissue is recommended for the malignant variant. 10 In summary, this is a case of a rare tumor on an uncommon location, with uncertain clinic behaviour and prognosis, which may represent a challenge when dealing with those lesions.


Conflict of interest: None

Financial funding: None

fn01* Study carried out at the Dermatovenereology Service of the Porto Hospital Center - Hospital Santo António (EPE-HSA) - Porto, Portugal.

1. Cavaleiro LHS,Viana FO,Carneiro CMM,Miranda MFR. Proliferating trichilemmal tumor - Case reportAn Bras DermatolYear: 2011861S190S19222068807
2. Falpe AL,Reisenauer AK,Mentzel T,Rütten A,Solomon AR. Proliferating trichilemmal tumors: Clinicopathologic evaluation is a guide to biologic behaviorJ Cutan PatholYear: 20033049249812950500
3. Pinkus H. "Sebaceous cysts" are trichilemmal cystsArch DermatolYear: 1969995445554181052
4. Noto G,Pravata G,Arico M. Proliferating tricholemmal cyst should always be considered as a low grade carcinomaDermatologyYear: 19971943743759252767
5. Ye J,Nappi O,Swanson PE,Patterson JW,Wick MR. Proliferating pilar tumors. A clinicopathologic study of 76 cases with a proposal for definition of benign and malignant variantsAm J Clin PatholYear: 200412256657415487455
6. Brownstein MH,Arluk DJ. Proliferating trichilemmal cyst: a stimulant of squamous cell carcinomaCancerYear: 198148120712146268280
7. Takeda H,Ikenaga S,Kaneko T,Nakajima K,Harada K,Hanada K,et al. Proliferating trichilemmal tumor developing in nevus sebaceousEur J DermatolYear: 20102066466520627855
8. Folpe AL,Reisenauer AK,Mentzel T,Rütten A,Solomon AR. Proliferating trichilemmal tumors: clinicopathologic evaluation is a guide to biologic behaviorJ Cutan PatholYear: 20033049249812950500
9. MacKie RM. Tumours of the skinRook A,Wilkinson DS,Ebling FJG,Champion RH,Burton JLTextbook of dermatology34th edSt. LouisBlackwell Mosby Book DistributorsYear: 198624052406
10. Satyaprakash AK,Sheehan JS,Sanguez OP. Proliferating trichilemmal tumors: a review of the literatureDermatol SurgYear: 2007331102110817760602


[Figure ID: f01]

Asymptomatic nodule on the nose

[Figure ID: f02]

A. Multilobular tumor (H&E, x 4). B. Peripheral palisading of small basaloid cells, differentiating towards large keratinocytes and abrupt keratinization (H&E, x 20)

[Figure ID: f03]

A. Areas of calcification with cholesterol crystals (H&E, x 10). B. Moderate nuclear atypia (H&E, x 20)

Article Categories:
  • Case Report

Keywords: Cysts, Nose neoplasms, Skin.

Previous Document:  Norwegian scabies mimicking rupioid psoriasis.
Next Document:  Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics.