Document Detail


Proliferating cell nuclear antigen (PCNA): ringmaster of the genome.
MedLine Citation:
PMID:  11682006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proliferating cell nuclear antigen (PCNA) protein is one of the central molecules responsible for decisions of life and death of the cell. The PCNA gene is induced by p53, while PCNA protein interacts with p53-controlled proteins Gadd45, MyD118, CR6 and, most importantly, p21, in the process of deciding cell fate. If PCNA protein is present in abundance in the cell in the absence of p53, DNA replication occurs. On the other hand, if PCNA protein levels are high in the cell in the presence of p53, DNA repair takes place. If PCNA is rendered non-functional or is absent or present in low quantities in the cell, apoptosis occurs. The evolution from prokaryotes to eukaryotes involved a change of function of PCNA from a 'simple' sliding clamp protein of the DNA polymerase complex to an executive molecule controlling critical cellular decision pathways. The evolution of multicellular organisms led to the development of multicellular processes such as differentiation, senescence and apoptosis. PCNA, already an essential molecule in the life of single cellular organisms, then became a protein critical for the survival of multicellular organisms.
Authors:
T Paunesku; S Mittal; M Protić; J Oryhon; S V Korolev; A Joachimiak; G E Woloschak
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  International journal of radiation biology     Volume:  77     ISSN:  0955-3002     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-29     Completed Date:  2001-12-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1007-21     Citation Subset:  IM; S    
Affiliation:
Biosciences Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439-4833, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Cell Survival
DNA Repair
Genome*
Humans
Molecular Sequence Data
Proliferating Cell Nuclear Antigen / chemistry,  genetics,  physiology*
Radiation Tolerance
Grant Support
ID/Acronym/Agency:
CA73042/CA/NCI NIH HHS; CA81375/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen

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