Document Detail


Proliferating activity in oral dysplastic leasions and squamous cell carcinomas.
MedLine Citation:
PMID:  11820602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was the quantitative analysis of AgNORs in oral squamous cell carcinomas as well as in dysplastic epithelial changes accompanied and not accompanied by oral squamous cell carcinomas. AgNOR proteins were visualized in histological slides using silver impregnation technique according to D. Ploton. In each sample 100 cell nuclei were assessed. The study used 54 cases of proliferating oral epithelial changes divided into 3 groups: group I consisting of 13 cases of dysplastic lesions not accompanied by oral squamous cell carcinomas; group II (a total of 18 cases) containing dysplastic lesions situated in the vicinity of oral carcinomas and group III (23 cases) with oral squamous cell carcinomas. Statistically significant differences were found between groups with mild dysplasia and groups with severe dysplasia as well as squamous cell carcinomas. Statistical analysis did not show any differences in the number of AgNORs between squamous cell carcinomas and epithelial lesions with severe dysplasia. Our results demonstrate that the analysis of AgNORs expression can serve only as an additional parameter to evaluate the potential of malignant transformation.
Authors:
M Sulkowska; W Famulski; I Kasacka; A Stasiak-Barmuta; S Sulkowski; D Miller-Famulska; M Koda
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  39 Suppl 2     ISSN:  0239-8508     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-31     Completed Date:  2002-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  191-2     Citation Subset:  IM    
Affiliation:
Department of Clinical Pathology, Medical Academy, Białystok, Poland. sulek@zeus.amb.edu.pl
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MeSH Terms
Descriptor/Qualifier:
Cell Division
Epithelial Cells / pathology
Humans
Mouth Neoplasms / pathology*
Neoplasms, Squamous Cell / pathology*
Nucleolus Organizer Region / pathology
Silver Staining

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