| Proliferating activity in the epithelial and stromal component of fibroadenomas and phyllodes tumours of the breast. | |
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MedLine Citation:
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PMID: 15638374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was an evaluation of PCNA and Ki-67 expression in the epithelial and stromal component of fibroepithelial tumours (FT) of the breast in correlation with morphological parameters. A series of 11 fibroadenomas (FA), including 8 cases of the cellular type (FAC), 19 benign phyllodes tumours (PTLGM), 8 bordeline (PTBM) and 6 malignant phyllodes tumours were assessed, using immunohistochemistry. The expressions of Ki-67 and PCNA in the epithelial component were significantly higher in PTLGM, when compared with FA and PTBM. A significant increase of Ki-67 and PCNA stromal expressions was associated with the progression from PTLGM to PTHGM. Our results show that Ki-67 and PCNA may be useful in the evaluation of stromal proliferation in phyllodes tumours (PT), which play an integral part in the progression from PTLGM through PTBM to PTHGM. |
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Authors:
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M Barwijuk-Machała; J Reszeć; M Baltaziak; B Musiatowicz; J Cylwik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Roczniki Akademii Medycznej w Białymstoku (1995) Volume: 49 Suppl 1 ISSN: - ISO Abbreviation: Rocz. Akad. Med. Bialymst. Publication Date: 2004 |
Date Detail:
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Created Date: 2005-01-10 Completed Date: 2005-03-15 Revised Date: 2006-01-06 |
Medline Journal Info:
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Nlm Unique ID: 9515551 Medline TA: Rocz Akad Med Bialymst Country: Poland |
Other Details:
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Languages: eng Pagination: 55-7 Citation Subset: IM |
Affiliation:
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Department of Pathology Medical University of Białystok, Poland. joasia@zpkamb.edu.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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pathology* Cell Division Epithelial Cells / pathology* Female Fibroadenoma / pathology* Humans Ki-67 Antigen / analysis Phyllodes Tumor / pathology* Proliferating Cell Nuclear Antigen / analysis Stromal Cells / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Ki-67 Antigen; 0/Proliferating Cell Nuclear Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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