Document Detail

Proliferating immature Schwann cells contribute to nerve regeneration after ischemic peripheral nerve injury.
MedLine Citation:
PMID:  22588387     Owner:  NLM     Status:  MEDLINE    
Schwann cells exhibit a high degree of plasticity in adult peripheral nerves after mechanical injury; they have, therefore, been implicated in promoting nerve regeneration. However, Schwann cell behavior after ischemic injury has not yet been elucidated. To determine how Schwann cell plasticity may contribute to recovery from ischemic neuropathy, we used a rat model in which ischemia was induced in the tibial nerve by a 5-hour occlusion of the supplying arteries. Proliferation of immature Schwann cells that emerged in the injured nerve was evaluated by double immunostaining for the p75 neurotrophin receptor and proliferating cell nuclear antigen. The number of proliferating cell nuclear antigen/p75 neurotrophin receptor double-positive cells increased significantly in 1 to 2 weeks after ischemia and subsequently decreased by 4 weeks. During this time, the postmitotic Schwann cells differentiated into mature cells, as demonstrated with bromodeoxyuridine incorporation, which facilitated axon guidance and subsequent axon remyelination. These results suggest the emergence and proliferation of immature Schwann cells that contribute to nerve regeneration after ischemic injury. The manipulation of this population of proliferating immature Schwann cells may be a useful strategy for treating ischemic peripheral neuropathy.
Masaki Kobayashi; Satoru Ishibashi; Hiroyuki Tomimitsu; Takanori Yokota; Hidehiro Mizusawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  71     ISSN:  1554-6578     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-22     Completed Date:  2012-07-16     Revised Date:  2012-12-07    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  511-9     Citation Subset:  IM    
Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
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MeSH Terms
Antimetabolites / diagnostic use
Axons / physiology
Bromodeoxyuridine / diagnostic use
Cell Count
Cell Proliferation
Functional Laterality / physiology
Hindlimb / blood supply,  innervation
Nerve Degeneration / pathology
Nerve Fibers, Myelinated / pathology
Nerve Regeneration / physiology*
Peripheral Nerve Injuries / pathology*
Recovery of Function / physiology
Regional Blood Flow / physiology
Reperfusion Injury / pathology
S100 Proteins / metabolism
Schwann Cells / physiology*
Tibial Nerve / pathology
Tissue Fixation
Reg. No./Substance:
0/Antimetabolites; 0/S100 Proteins; 59-14-3/Bromodeoxyuridine

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