Document Detail


Prolactin's role in the pathogenesis of the antiphospholipid syndrome.
MedLine Citation:
PMID:  20647249     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Increased levels of serum prolactin have been reported in patients with various autoimmune diseases and have been associated with lupus disease activity. Currently, there is a lack of data regarding hyperprolactinaemia in patients with the antiphospholipid syndrome. Hence, this study was carried out in order to evaluate the prevalence and clinical significance of hyperprolactinaemia in antiphospholipid syndrome. A total of 172 European patients with antiphospholipid syndrome and 100 geographically and sex-matched healthy controls were included in the study; none had obvious causes of hyperprolactinaemia. All patients underwent clinical assessment for disease manifestations, in addition to laboratory assessment for serum prolactin, antiphospholipid antibodies and some other biomarkers of autoimmune diseases. The tests were performed utilizing the LIAISON® Analyzer (DiaSorin, Sallugia Italy). Hyperprolactinaemia was detected in 21/172 patients with antiphospholipid syndrome and 0/100 controls (p < 0.001). This significant difference was present in both genders and was obvious even after subgrouping the patients into primary and secondary antiphospholipid syndrome. When clinical features were compared, hyperprolactinaemia was associated with reproductive failure, including early and late pregnancy loss (p < 0.05), as well as intrauterine growth retardation (p < 0.05). Hyperprolactinaemia was negatively related to arthralgias, venous thrombosis, pulmonary microthrombosis, pulmonary hypertension in both primary antiphospholipid syndrome and antiphospholipid syndrome secondary to other diseases, and to neurological manifestations in primary antiphospholipid syndrome (p<0.05). The data indirectly imply that prolactin may play a role in the pathogenesis of antiphospholipid syndrome, especially antiphospholipid syndrome-related reproductive failure.
Authors:
S Praprotnik; N Agmon-Levin; B S Porat-Katz; M Blank; P L Meroni; R Cervera; W Miesbach; L Stojanovich; M Szyper-Kravitz; B Rozman; M Tomsic; Y Shoenfeld
Related Documents :
16088419 - Cardiac thrombus in omenn syndrome.
21428179 - The association between homocysteine level and metabolic syndrome in patients of prior ...
8358989 - Sneddon's syndrome and phospholipid antibodies.
16465669 - Rituximab treatment for resistant antiphospholipid syndrome.
11204029 - Catastrophic antiphospholipid syndrome in cancer.
17222839 - Isolated type 5 antimitochondrial autoantibodies are associated with a history of throm...
24024059 - A case of monozygotic twins: the value of discordant monozygotic twins in goldenhar syn...
18518849 - Pharmacogenetics of gilbert's syndrome.
2633769 - Transient global amnesia associated with cerebral angiography performed with use of iop...
Publication Detail:
Type:  Journal Article     Date:  2010-07-20
Journal Detail:
Title:  Lupus     Volume:  19     ISSN:  1477-0962     ISO Abbreviation:  Lupus     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  1515-9     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, University Clinical Center Ljubljana, Ljubljana, Slovenia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nationwide population-based epidemiologic study of systemic lupus erythematosus in Taiwan.
Next Document:  Characterization of the metabolic phenotype of chronically activated lymphocytes.