Document Detail

Prolactin stimulates food intake in the absence of ovarian progesterone.
MedLine Citation:
PMID:  2923259     Owner:  NLM     Status:  MEDLINE    
Increases in serum estrogen inhibit food intake. Conversely, progesterone stimulates food intake, probably via its antiestrogenic action. We have reported that elevated serum prolactin also stimulates food intake in female rats. It is unclear whether this effect is mediated through elevated levels of progesterone. The present study investigated the effects of prolactin on food intake and brown fat activity in the absence of progesterone. Female Osborne-Mendel rats were assigned to one of six groups: sham operated (Sham, n = 10), ovariectomized (OVX, n = 10), OVX + low estrogen (EL, n = 11), OVX + EL + prolactin (PIT, n = 9), OVX + high estrogen (EH, n = 10), and OVX + EH + PIT (n = 8). Estrogen levels were elevated by Silastic implants. Prolactin levels were elevated through pituitary transplants placed under the kidney capsule. Nine days postsurgery, food intake was significantly higher in OVX vs. Sham rats. Estrogen-treated rats (OVX + EL and OVX + EH) had significantly suppressed food intake values compared with both Sham and OVX animals. Finally, hyperprolactinemic rats (OVX + EL + PIT and OVX + EH + PIT) ate significantly more food than did estrogen-treated rats without pituitary explants. Despite the hyperphagia, no significant differences in brown fat GDP binding were observed. These data indicate that prolactin stimulates food intake in the absence of ovarian progesterone.
T Gerardo-Gettens; B J Moore; J S Stern; B A Horwitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  256     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-12     Completed Date:  1989-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R701-6     Citation Subset:  IM    
Department of Animal Physiology and Nutrition, University of California, Davis 95616.
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MeSH Terms
Adipose Tissue, Brown / drug effects,  physiology
Dose-Response Relationship, Drug
Energy Intake
Estradiol / pharmacology*
Feeding Behavior / drug effects*
Progesterone / physiology*
Prolactin / pharmacology*
Rats, Inbred Strains
Reference Values
Silicone Elastomers
Grant Support
Reg. No./Substance:
0/Silicone Elastomers; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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