Document Detail


Prolactin secretion by human chorion-decidua in vitro: influences of mode of delivery and agents that modify prostaglandin synthesis.
MedLine Citation:
PMID:  6614083     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolactin production by human decidua was examined with the use of a short-term tissue explant system. Decidua obtained after normal spontaneous vaginal deliveries produced significantly more prolactin than did tissue obtained after elective repeat cesarean section deliveries in the absence of labor (P less than 0.005). Cytosolic prolactin levels did not differ between the two delivery modes. Oxytocin (4.3 X 10(-11) M to 4.3 X 10(-6) M) and eicosatetraenoic acid (10(-7) M to 10(-4) M) had no effect on prolactin production or storage by decidual tissue. Indomethacin at 10(-4) M reduced only levels of stored prolactin but had no effect on stored or produced prolactin at lower concentrations (10(-7) M to 10(-5) M). Arachidonic acid (10(-4) M) suppressed both production and storage of prolactin (P less than 0.05). Decidual tissue from the two delivery modes did not differ in response to the above agents. Although the exact mechanism(s) remains obscure, these results indicate decidual prolactin production is altered by some aspect of labor. The possible involvement of prostaglandin precursors in mediating this production cannot be excluded.
Authors:
E C Krug; A D Rogol; W D Jarvis; S Thiagarajah; C A Singhas
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  147     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acids / pharmacology
Cesarean Section
Chorion / drug effects,  secretion*
Decidua / drug effects,  secretion*
Female
Humans
Indomethacin / pharmacology
Male
Oxytocin / pharmacology
Pregnancy
Prolactin / secretion*
Prostaglandins / biosynthesis*
Reoperation
Grant Support
ID/Acronym/Agency:
HD-13893/HD/NICHD NIH HHS; K-04AM00153/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 50-56-6/Oxytocin; 53-86-1/Indomethacin; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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