Document Detail

Prolactin-secreting macroadenoma in a prepubertal girl.
MedLine Citation:
PMID:  9840387     Owner:  NLM     Status:  MEDLINE    
Prolactin-secreting adenoma, which usually presents with amenorrhea and galactorrhea syndrome, is quite rarely diagnosed in the prepubertal age group. We reported a rare case of a prepubertal prolactin-secreting adenoma and discuss its clinical, radiological and histological features. An 8-year-old girl presented with headache, progressive visual deterioration and precocious puberty. The serum prolactin level was 57.8 ng/ml. Computerized tomography and magnetic resonance imaging revealed an invasive suprasellar tumor. The tumor was partially resected through an interhemispheric approach in a first operation, and residual tumor was resected through the right pterional approach in a second operation. The histological diagnosis was a prolactin-secreting adenoma with high cellular pleomorphism. The Ki-67 labeling index was 5.7%, indicating aggressive biological behavior. Postoperatively, the patient was prescribed bromocriptine as maintenance therapy, and the serum prolactin level became normalized. There is a tendency for diagnosis of a prepubertal prolactin-secreting adenoma to be delayed because there are no endocrinological manifestations. Therefore, the tumor tends to become larger and invasive. Although it is rarely experienced, a prolactin-secreting adenoma should be considered in the differential diagnosis of a large, invasive parasellar lesion in the prepubertal age group.
S Kashiwagi; T Nishizaki; K Harada; H Ito; M Setoguchi; M Takahashi; T Ishihara
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  14     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-02-11     Completed Date:  1999-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  602-5     Citation Subset:  IM    
Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Japan.
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MeSH Terms
Bromocriptine / therapeutic use
Combined Modality Therapy
Hormone Antagonists / therapeutic use
Magnetic Resonance Imaging
Pituitary Neoplasms / blood,  diagnosis*,  pathology,  surgery
Postoperative Care
Prolactin / blood
Prolactinoma / blood,  diagnosis*,  pathology,  surgery
Tomography, X-Ray Computed
Reg. No./Substance:
0/Hormone Antagonists; 25614-03-3/Bromocriptine; 9002-62-4/Prolactin

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