| Prolactin-releasing peptide regulates the cardiovascular system via corticotrophin-releasing hormone. | |
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MedLine Citation:
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PMID: 19500229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prolactin-releasing peptide (PrRP)-producing neurones are known to be localised mainly in the medulla oblongata and to act as a stress mediator in the central nervous system. In addition, central administration of PrRP elevates the arterial pressure and heart rate. However, the neuronal pathway of the cardiovascular effects of PrRP has not been revealed. In the present study, we demonstrate that PrRP-immunoreactive neurones projected to the locus coeruleus (LC) and the paraventricular nucleus (PVN) of the hypothalamus. The c-fos positive neurones among the noradrenaline cells in the LC, and the parvo- and magnocellular neurones in the PVN, were increased after central administration of PrRP. The arterial pressure and heart rate were both elevated after i.c.v. administration of PrRP. Previous studies have demonstrated that PrRP stimulated the neurones in the PVN [i.e. oxytocin-, vasopressin- and corticotrophin-releasing hormone (CRH)-producing neurones], which suggests that PrRP may induce its cardiovascular effect via arginine vasopressin (AVP) or CRH. Although the elevation of blood pressure and heart rate elicited by PrRP administration were not inhibited by an AVP antagonist, they were completely suppressed by treatment with a CRH antagonist. Thus, we conclude that PrRP stimulated CRH neurones in the PVN and that CRH might regulate the cardiovascular system via the sympathetic nervous system. |
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Authors:
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T Yamada; A Mochiduki; Y Sugimoto; Y Suzuki; K Itoi; K Inoue |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroendocrinology Volume: 21 ISSN: 1365-2826 ISO Abbreviation: J. Neuroendocrinol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-08 Completed Date: 2009-08-24 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8913461 Medline TA: J Neuroendocrinol Country: England |
Other Details:
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Languages: eng Pagination: 586-93 Citation Subset: IM |
Affiliation:
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Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University, Sakura-ku, Saitama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Cardiovascular System / metabolism* Corticotropin-Releasing Hormone / antagonists & inhibitors, metabolism* Heart Rate / physiology Hypothalamic Hormones / genetics, metabolism* Hypothalamus / anatomy & histology, metabolism Locus Coeruleus / cytology, metabolism Male Neural Pathways / anatomy & histology, physiology Neurons / cytology, metabolism Norepinephrine / metabolism Prolactin-Releasing Hormone Proto-Oncogene Proteins c-fos / metabolism Rats Rats, Wistar Tyrosine 3-Monooxygenase / metabolism Vasopressins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Hypothalamic Hormones; 0/Prlh protein, rat; 0/Prolactin-Releasing Hormone; 0/Proto-Oncogene Proteins c-fos; 11000-17-2/Vasopressins; 51-41-2/Norepinephrine; 9015-71-8/Corticotropin-Releasing Hormone; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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