Document Detail

Prolactin and related peptides in pregnancy.
MedLine Citation:
PMID:  2248596     Owner:  NLM     Status:  MEDLINE    
This brief review has attempted to portray the complex involvement of prolactin in pregnancy. Pituitary prolactin production and lactotroph proliferation are markedly affected by oestrogens and pregnancy. Enlargement of pre-existing prolactinomas may occur during pregnancy induced with dopamine agonist drugs, and this can be a major clinical problem with larger tumours. Prolactin is produced by late luteal and decidualized endometrium as well as by the pituitary gland, but much less is known about its secretory regulation or its function. The family of prolactin-related protein hormones is rapidly expanding with the recognition of placental lactogens, variant growth hormone, proliferin, decidual luteotropin, and at least two further prolactin-related peptides in rodents. This complex system of related but distinct protein hormones, with different temporal patterns of production during gestation, suggests an important physiological role, but it remains to be seen to what extent they are involved in placental function itself, maternal metabolism or fetal growth.
J R Davis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Baillière's clinical endocrinology and metabolism     Volume:  4     ISSN:  0950-351X     ISO Abbreviation:  Baillieres Clin. Endocrinol. Metab.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1991-01-04     Completed Date:  1991-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8704785     Medline TA:  Baillieres Clin Endocrinol Metab     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-90     Citation Subset:  IM    
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MeSH Terms
Glycoproteins / physiology
Intercellular Signaling Peptides and Proteins
Pituitary Neoplasms / metabolism,  therapy
Placenta / metabolism
Placental Lactogen / physiology
Pregnancy / physiology*
Pregnancy Complications, Neoplastic
Prolactin / biosynthesis,  physiology*
Prolactinoma / metabolism,  therapy
Uterus / metabolism
Reg. No./Substance:
0/Glycoproteins; 0/Intercellular Signaling Peptides and Proteins; 0/Plf protein, mouse; 9002-62-4/Prolactin; 9035-54-5/Placental Lactogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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