| Prolactin and the regulation of adipose-tissue metabolism during lactation in rats. | |
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MedLine Citation:
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PMID: 7016633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Removal of litters from young lactating rats for 24 or 48 h or treatment of lactating rats with bromocriptine increased the rate of fatty acid synthesis and the activities of lipoprotein lipase and fatty acid synthetase in adipose tissue, decreased the lipoprotein lipase and fatty acid synthetase activities of mammary gland and lowered the serum-prolactin concentration. Concurrent injections of prolactin prevented the effects of bromocriptine and 24 h of litter removal on most of these changes in adipose tissue, but did not prevent the effects of 48 h of litter removal. The results suggest that effects of prolactin on adipose-tissue metabolism are dependent on a functional mammary gland. Most of the responses of adipose tissue to litter removal were reduced in older rats. |
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Authors:
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D J Flint; R A Clegg; R G Vernon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 22 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 1981 May |
Date Detail:
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Created Date: 1981-08-20 Completed Date: 1981-08-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 265-75 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects,
metabolism* Animals Bromocriptine / pharmacology Fatty Acid Synthetase Complex / metabolism Fatty Acids / biosynthesis Female Insulin / blood Lactation* Lipoprotein Lipase / metabolism Pregnancy Prolactin / blood, pharmacology* Rats Receptor, Insulin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 11061-68-0/Insulin; 25614-03-3/Bromocriptine; 9002-62-4/Prolactin; EC 2.7.10.1/Receptor, Insulin; EC 3.1.1.34/Lipoprotein Lipase; EC 6.-/Fatty Acid Synthetase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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