Document Detail

Prolactin and the regulation of adipose-tissue metabolism during lactation in rats.
MedLine Citation:
PMID:  7016633     Owner:  NLM     Status:  MEDLINE    
Removal of litters from young lactating rats for 24 or 48 h or treatment of lactating rats with bromocriptine increased the rate of fatty acid synthesis and the activities of lipoprotein lipase and fatty acid synthetase in adipose tissue, decreased the lipoprotein lipase and fatty acid synthetase activities of mammary gland and lowered the serum-prolactin concentration. Concurrent injections of prolactin prevented the effects of bromocriptine and 24 h of litter removal on most of these changes in adipose tissue, but did not prevent the effects of 48 h of litter removal. The results suggest that effects of prolactin on adipose-tissue metabolism are dependent on a functional mammary gland. Most of the responses of adipose tissue to litter removal were reduced in older rats.
D J Flint; R A Clegg; R G Vernon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  22     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  265-75     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / drug effects,  metabolism*
Bromocriptine / pharmacology
Fatty Acid Synthetase Complex / metabolism
Fatty Acids / biosynthesis
Insulin / blood
Lipoprotein Lipase / metabolism
Prolactin / blood,  pharmacology*
Receptor, Insulin / metabolism
Reg. No./Substance:
0/Fatty Acids; 11061-68-0/Insulin; 25614-03-3/Bromocriptine; 9002-62-4/Prolactin; EC, Insulin; EC Lipase; EC 6.-/Fatty Acid Synthetase Complex

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