Document Detail


Prolactin levels in umbilical cord serum and its relation to fetal adrenal activity in newborns of women with pregnancy-induced hypertension.
MedLine Citation:
PMID:  3748660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of hypertension in pregnant women on fetal maturation is an issue of considerable importance. Because of a possible role of prolactin in fetal adrenal steroidogenesis and in fetal lung maturation, we have investigated the relationship between hypertension in pregnant women and levels of prolactin and dehydroepiandrosterone sulfate in serum of newborn infants. It was found that with the mild-to-moderate form of pregnancy-induced hypertension (PIH), there was little effect on prolactin levels in newborn serum. In newborns of women with severe PIH, however, serum prolactin levels were significantly greater (p less than 0.01) than those in newborns of women with uncomplicated pregnancies. Conversely, umbilical serum concentrations of dehydroepiandrosterone sulfate in newborns of women with severe PIH were significantly less (p less than 0.05) than those in newborns of women with uncomplicated pregnancies. These findings are supportive of the view that pituitary function and adrenocortical function of fetuses of women with PIH are different from those of fetuses of normotensive women. These findings are suggestive that PIH alters the function of the fetal pituitary and adrenal cortex.
Authors:
C R Parker; G D Hankins; B R Carr; N F Gant; P C MacDonald; J C Porter
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  20     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-22     Completed Date:  1986-10-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  876-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / embryology,  physiology*
Female
Fetal Blood / analysis*
Humans
Hypertension / physiopathology*
Infant, Newborn
Maternal-Fetal Exchange
Pregnancy
Pregnancy Complications, Cardiovascular / physiopathology*
Prolactin / blood*
Umbilical Cord
Grant Support
ID/Acronym/Agency:
HD13912/HD/NICHD NIH HHS; HD14513/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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