| Prolactin inhibition in dams during lactation programs for overweight and leptin resistance in adult offspring. | |
| | |
MedLine Citation:
|
PMID: 17283233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Maternal malnutrition during lactation reduces prolactin (PRL) and milk production, alters milk composition, and programs the body weight of the offspring. Our study aimed to evaluate the long-term effects of maternal hypoprolactinemia at the end of lactation on food ingestion, body weight, amount of retroperitoneal white adipose tissue (RPWAT), leptinemia, and anorectic leptin effect in the adult offspring. Lactating rats were treated with bromocriptine (BRO), a PRL inhibitor, 1 mg twice a day, or saline (C - control) for the last 3 days of lactation. The body weight and food intake were monitored, and after sacrifice at 180 days, the RPWAT was weighted. In a second experiment, the anorectic leptin effect was tested on 180-day-old animals. Adult offspring whose mothers were BRO-treated showed higher body weight (10%), higher amount of RPWAT (2 x 3 times), higher total body fat (+39%), and hyperleptinemia (2 x 9 times) when compared with C, although food intake did not alter. After injection of leptin, the food ingestion at 2, 4 and 6 h was unaffected in BRO animals, confirming a resistance to the anorectic effect of leptin. Since the maternal PRL inhibition during lactation programs, a higher body weight with no alteration of food ingestion, we suggest a hypometabolic state. The leptin anorectic resistance can be due to the hyperleptinemia. We suggest that PRL changes during lactation can regulate body weight during adulthood. |
| | |
Authors:
|
Isabela Teixeira Bonomo; Patricia Cristina Lisboa; Analaura Ribeiro Pereira; Magna Cottini Fonseca Passos; Egberto Gaspar de Moura |
Related Documents
:
|
17204073 - Myrmecophilic food body production in the understorey tree, ryparosa kurrangii (acharia... 7667433 - Influence of period length of light/dark cycles on the body weight and food intake of y... 1879493 - A large outbreak of gastroenteritis associated with a small round structured virus amon... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of endocrinology Volume: 192 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-02-06 Completed Date: 2007-04-12 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 339-44 Citation Subset: IM |
Affiliation:
|
Departmento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de setembro, 87 Rio de Janeiro, RJ, 20551-030, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
metabolism Animals Body Weight Bromocriptine Eating Female Lactation* Leptin / metabolism*, pharmacology Maternal Nutritional Physiological Phenomena Nutritional Status Overweight / physiology* Prolactin / antagonists & inhibitors, blood, deficiency* Rats Rats, Wistar Weaning |
| Chemical | |
Reg. No./Substance:
|
0/Leptin; 25614-03-3/Bromocriptine; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of polychlorinated biphenyl (Aroclor 1254) on steroidogenesis and antioxidant system in cult...
Next Document: Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rat...