| Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB. | |
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MedLine Citation:
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PMID: 18248819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of immune-neuroendocrine interactions in the autoimmune diseases is well recognized. Autoimmune rheumatoid diseases in their active phase have been characterized by high levels of prolactin (PRL) as well as proinflammatory cytokines which suggest a co-relationship between them. In the present study, we have investigated the profile of cytokines secreted by macrophages on treatment with PRL and growth hormone (GH) in vitro. Significantly enhanced production of cytokines IL-1beta, IL-12p40 and IFN-gamma was observed on treatment of macrophages with PRL or GH. However, higher doses of PRL (1000 ng/ml) induced the production of anti-inflammatory cytokine IL-10, with significant abrogation in production of proinflammatory cytokines. It is further observed that PRL and GH induced the production of chemokines MIP-1alpha and RANTES. PRL but not GH selectively induced significantly enhanced production of MCP-1 and IP-10. It is further shown that p38 MAP kinase, STAT3 and NF-kappaB could play a differential regulatory role in PRL or GH induced production of cytokines by macrophages. |
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Authors:
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Ajit Sodhi; Anurag Tripathi |
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Publication Detail:
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Type: Journal Article Date: 2008-01-08 |
Journal Detail:
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Title: Cytokine Volume: 41 ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-02-21 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 162-73 Citation Subset: IM |
Affiliation:
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School of Biotechnology, Faculty of Science, Banaras Hindu University, Varanasi, UP 221005, India. ajit.sodhi@lycos.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Chemokine CCL2 / biosynthesis Chemokine CCL3 / biosynthesis Chemokine CCL5 / biosynthesis Chemokine CXCL10 / biosynthesis Chemokines / biosynthesis* Curcumin / pharmacology Cytokines / biosynthesis* Female Growth Hormone / pharmacology* I-kappa B Proteins / biosynthesis Imidazoles / pharmacology Interferon-gamma / biosynthesis Interleukin-10 / biosynthesis Interleukin-12 Subunit p40 / biosynthesis Interleukin-1beta / biosynthesis Kinetics Macrophages, Peritoneal / drug effects*, metabolism* Male Mice Mice, Inbred BALB C NF-kappa B / physiology* Phosphorylation Polymyxin B / pharmacology Prolactin / pharmacology* Pyridines / pharmacology STAT3 Transcription Factor / physiology* Tyrphostins / pharmacology p38 Mitogen-Activated Protein Kinases / physiology* |
| Chemical | |
Reg. No./Substance:
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0/4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; 0/Ccl2 protein, mouse; 0/Chemokine CCL2; 0/Chemokine CCL3; 0/Chemokine CCL5; 0/Chemokine CXCL10; 0/Chemokines; 0/Cytokines; 0/I-kappa B Proteins; 0/Imidazoles; 0/Interleukin-12 Subunit p40; 0/Interleukin-1beta; 0/NF-kappa B; 0/Pyridines; 0/STAT3 Transcription Factor; 0/Stat3 protein, mouse; 0/Tyrphostins; 0/alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide; 130068-27-8/Interleukin-10; 1404-26-8/Polymyxin B; 458-37-7/Curcumin; 82115-62-6/Interferon-gamma; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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