Document Detail

Prolactin and cortisol responses to fenfluramine challenge in mania.
MedLine Citation:
PMID:  8645775     Owner:  NLM     Status:  MEDLINE    
Prolactin and cortisol responses to fenfluramine (60 mg PO) challenge were examined in 20 subjects (10 manic patients and 10 age- and gender-matched healthy controls) to ascertain the "net" central serotonin (5-HT) activity in mania. There was no difference in baseline prolactin or cortisol levels between manic patients and healthy controls. Similarly, neither prolactin nor cortisol response to fenfluramine was different in manic patients compared to controls. There was also no correlation between severity of symptoms in manic patients and prolactin or cortisol response to fenfluramine challenge. The results do not support the possibility that net central 5-HT activity is altered in mania.
L N Yatham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  39     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-07-19     Completed Date:  1996-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-8     Citation Subset:  IM    
Department of Psychiatry, Dalhousie University, Nova Scotia Hospital, Dartmouth, Canada.
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MeSH Terms
Arousal / physiology*
Bipolar Disorder / diagnosis*,  physiopathology,  psychology
Brain / physiopathology
Fenfluramine / diagnostic use*
Hydrocortisone / blood*
Middle Aged
Prolactin / blood*
Serotonin / physiology
Serotonin Uptake Inhibitors / diagnostic use*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 458-24-2/Fenfluramine; 50-23-7/Hydrocortisone; 50-67-9/Serotonin; 9002-62-4/Prolactin

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