| Prolactin-cell adenoma with signet-ring cells: a case report. | |
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MedLine Citation:
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PMID: 21726505 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: Signet-ring cell changes in the pituitary adenomas are extremely rare. To date, there have been only two reports documenting signet-ring cells in pituitary adenomas, one in a growth-hormone cell adenoma and the other in a nullcell adenoma. This report describes, for the first time, signet-ring cells in a prolactincell adenoma. Case history: The patient is a 46-year-old male who presented with severe headache and acute on chronic visual loss. Radiographic studies demonstrated a large cystic pituitary lesion with evidence of pituitary apoplexy. Laboratory values were consistent with a prolactin-cell adenoma. The patient underwent transsphenoidal resection of the prolactin-cell adenoma with significant post-operative improvement. Results: The tumor was composed of sheets of monomorphic round cells with conspicuous nuclei and granular cytoplasm, consistent with pituitary adenoma. Many cells had eccentric, often crescentic-shaped nuclei, imparting a signet-ring appearance and immunostaining was positive for prolactin, denoting an atypical prolactin-cell adenoma. The MIB-1 labeling index was slightly elevated. Electron microscopy demonstrated the presence of vacuolated areas in the cytoplasm that were not membrane bound and did not have specific inclusions. Discussion: This case augments the literature on pituitary adenomas with signet-ring cells. The clinical significance of signet-ring cells in pituitary adenomas is unknown. Accumulation of clinical cases, together with the advances in molecular techniques and experimental models, may yield further insight. |
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Authors:
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E Binello; C Cunliffe; K D Post; G M Kleinman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical neuropathology Volume: 30 ISSN: 0722-5091 ISO Abbreviation: Clin. Neuropathol. Publication Date: 2011 Jul-Aug |
Date Detail:
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Created Date: 2011-07-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214420 Medline TA: Clin Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 192-6 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, and Division of Neuropathology, Department of Pathology, Mount Sinai Medical Center, New York, NY, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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