| Prokinetics and fundic relaxants in upper functional GI disorders. | |
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MedLine Citation:
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PMID: 18940266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastrointestinal prokinetics are a heterogeneous class of drugs that stimulate smooth muscle contractions to enhance gastric emptying and intestinal transit. Recently studied prokinetics include antidopaminergic agents (itopride), serotonergic agents (tegaserod and others), and motilin receptor agonists and ghrelin receptor agonists (mitemcinal, TZP101). It has been difficult to establish symptomatic benefit with prokinetic drugs in gastroparesis and functional dyspepsia, because of pathophysiological heterogeneity of the patient populations, a lack of well-accepted endpoints, and inconsistent relationships between changes in motor function and symptomatic outcome. Fundic relaxant drugs are a recent different approach to treatment of gastric motility disorders. Recently studied drugs include drugs under investigation including nitrates, serotonin reuptake blockers, 5-HT(1A) receptor agonists (buspirone and R137696), and muscarinc M1/M2 receptor antagonists (acotiamide or Z-338). |
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Authors:
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Jan Tack |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-10-27 |
Journal Detail:
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Title: Current opinion in pharmacology Volume: 8 ISSN: 1471-4892 ISO Abbreviation: Curr Opin Pharmacol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-17 Completed Date: 2009-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966133 Medline TA: Curr Opin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 690-6 Citation Subset: IM |
Affiliation:
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Center for Gastroenterological Research, KU Leuven, Belgium. Jan.Tack@med.kuleuven.ac.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gastric Fundus / drug effects*, pathology, physiopathology Gastrointestinal Agents / pharmacology, therapeutic use* Gastrointestinal Diseases / drug therapy*, physiopathology Gastrointestinal Motility / drug effects Humans Models, Biological Muscle Relaxation / drug effects Muscle, Smooth / drug effects*, pathology, physiopathology Upper Gastrointestinal Tract / drug effects*, pathology, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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