| Prokaryotic toxin-antitoxin systems - the role in bacterial physiology and application in molecular biology. | |
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MedLine Citation:
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PMID: 21394325 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Bacteria have developed multiple complex mechanisms ensuring an adequate response to environmental changes. In this context, bacterial cell division and growth are subject to strict control to ensure metabolic balance and cell survival. A plethora of studies cast light on toxin-antitoxin (TA) systems as metabolism regulators acting in response to environmental stress conditions. Many of those studies suggest direct relations between the TA systems and the pathogenic potential or antibiotic resistance of relevant bacteria. Other studies point out that TA systems play a significant role in ensuring stability of mobile genetic material. Evolutionary origin and relations between various TA systems are still a subject of a debate. The impact of toxin-antitoxin systems on bacteria physiology prompted their application in molecular biology as tools allowing cloning of some hard-to-maintain genes, plasmid maintenance and production of recombinant proteins. |
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Authors:
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Michal Bukowski; Anna Rojowska; Benedykt Wladyka |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-11 |
Journal Detail:
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Title: Acta biochimica Polonica Volume: - ISSN: 1734-154X ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 14520300R Medline TA: Acta Biochim Pol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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