| Projections to the anterodorsal thalamus and lateral mammillary nuclei arise from different cell populations within the postsubiculum: implications for the control of head direction cells. | |
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MedLine Citation:
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PMID: 20575008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neural representation of directional heading is encoded by a population of cells located in a circuit that includes the postsubiculum (PoS), anterodorsal thalamus (ADN), and lateral mammillary nuclei (LMN). Throughout this circuit, many cells rely on both movement- and landmark-related information to discharge as a function of the animal's directional heading. The PoS projects to both the ADN and LMN, and these connections may convey critical spatial information about landmarks, because lesions of the PoS disrupt landmark control in head direction (HD) cells and hippocampal place cells [Goodridge and Taube (1997) J Neurosci 17:9315-9330; Calton et al. (2003) J Neurosci 23:9719-9731]. The PoS → ADN projection originates in the deep layers of PoS, but no studies have determined whether the PoS → LMN projection originates from the same cells that project to ADN. To address this issue, two distinct cholera toxin-subunit B (CTB) fluorophore conjugates (Alexa Fluor 488 and Alexa Fluor 594) were injected into the LMN and ADN of the same rats, and PoS sections were examined for cell bodies containing either or both CTB conjugates. Results indicated that the PoS → LMN projection originates exclusively from a thin layer of cells located superficial to the layer(s) of PoS → ADN projection cells, with no overlap. To verify the laminar distribution and morphological characteristics of PoS → LMN and PoS → ADN cells, biotinylated dextran amine was injected into LMN or ADN of different rats, and tissue sections were counterstained with thionin. Results indicated that the PoS → LMN projection arises from large pyramidal cells in layer IV, whereas the PoS → ADN projection arises from a heterogeneous cell population in layers V/VI. This study provides the first evidence that the PoS → ADN and PoS → LMN projections arise from distinct, nonoverlapping cell layers in PoS. Functionally, the PoS may provide landmark information to HD cells in LMN. |
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Authors:
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Ryan M Yoder; Jeffrey S Taube |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-06-23 |
Journal Detail:
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Title: Hippocampus Volume: 21 ISSN: 1098-1063 ISO Abbreviation: Hippocampus Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-28 Completed Date: 2012-04-02 Revised Date: 2013-05-14 |
Medline Journal Info:
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Nlm Unique ID: 9108167 Medline TA: Hippocampus Country: United States |
Other Details:
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Languages: eng Pagination: 1062-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Animals Anterior Thalamic Nuclei / physiology* Brain Mapping* Female Head Movements / physiology* Hippocampus / cytology, physiology* Mamillary Bodies / physiology* Nerve Net / physiology Neural Pathways / physiology Orientation / physiology Pyramidal Cells / physiology* Rats Rats, Long-Evans Space Perception / physiology Visual Cortex / physiology |
| Grant Support | |
ID/Acronym/Agency:
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F32 DC008481/DC/NIDCD NIH HHS; F32 DC84812/DC/NIDCD NIH HHS; R01 DC009318-04/DC/NIDCD NIH HHS; R01 NS053907/NS/NINDS NIH HHS; R01 NS053907/NS/NINDS NIH HHS; R01 NS053907-11/NS/NINDS NIH HHS; R01 NS053907-12/NS/NINDS NIH HHS; R01 NS053907-13/NS/NINDS NIH HHS; R01 NS053907-14/NS/NINDS NIH HHS; R01 NS053907-14S1/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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