| Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination. | |
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MedLine Citation:
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PMID: 19523794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In project DyAdd, we compared the fatty acid (FA) profiles of serum phospholipids in adults with attention deficit hyperactivity disorder (ADHD) (n=26), dyslexia (n=36), their comorbid combination (n=9), and healthy controls (n=36). FA proportions were analyzed in a 2x2 design with Bonferroni corrected post hoc comparisons. A questionnaire was used to assess dietary fat quality and use of supplements. Results showed that ADHD and dyslexia were not associated with total saturated FAs, monounsaturated FAs, or n-3 polyunsaturated FAs (PUFAs). However, those with ADHD had elevated proportions of total n-6 PUFAs (including gamma-linolenic and adrenic acids) as compared to those without ADHD. Dyslexia was related to a higher proportion of monounsaturated nervonic acid and a higher ratio of n-6/n-3 PUFAs. Among females none of the associations were significant. However in males, all the original associations observed in all subjects remained and ADHD was associated with elevated nervonic acid and n-6/n-3 PUFA ratio like dyslexia. Controlling for poorly diagnosed reading difficulties, education, dietary fat quality, or use of FA supplements did not generally remove the originally observed associations. |
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Authors:
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Marja Laasonen; Laura Hokkanen; Sami Leppämäki; Pekka Tani; Arja T Erkkilä |
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Publication Detail:
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Type: Journal Article Date: 2009-06-11 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 81 ISSN: 1532-2823 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-06 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 89-96 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Helsinki, P.O. Box 9 (Siltavuorenpenger 20), FIN-00014, Helsinki, Finland. Marja.Laasonen@helsinki.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Attention Deficit Disorder with Hyperactivity / blood*, epidemiology Comorbidity Dyslexia / blood*, epidemiology Fatty Acids / blood* Fatty Acids, Omega-3 / blood Fatty Acids, Omega-6 / blood Fatty Acids, Unsaturated / blood Female Finland / epidemiology Humans Male Middle Aged Questionnaires |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated |
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