Document Detail


Project DyAdd: Fatty acids in adult dyslexia, ADHD, and their comorbid combination.
MedLine Citation:
PMID:  19523794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In project DyAdd, we compared the fatty acid (FA) profiles of serum phospholipids in adults with attention deficit hyperactivity disorder (ADHD) (n=26), dyslexia (n=36), their comorbid combination (n=9), and healthy controls (n=36). FA proportions were analyzed in a 2x2 design with Bonferroni corrected post hoc comparisons. A questionnaire was used to assess dietary fat quality and use of supplements. Results showed that ADHD and dyslexia were not associated with total saturated FAs, monounsaturated FAs, or n-3 polyunsaturated FAs (PUFAs). However, those with ADHD had elevated proportions of total n-6 PUFAs (including gamma-linolenic and adrenic acids) as compared to those without ADHD. Dyslexia was related to a higher proportion of monounsaturated nervonic acid and a higher ratio of n-6/n-3 PUFAs. Among females none of the associations were significant. However in males, all the original associations observed in all subjects remained and ADHD was associated with elevated nervonic acid and n-6/n-3 PUFA ratio like dyslexia. Controlling for poorly diagnosed reading difficulties, education, dietary fat quality, or use of FA supplements did not generally remove the originally observed associations.
Authors:
Marja Laasonen; Laura Hokkanen; Sami Leppämäki; Pekka Tani; Arja T Erkkilä
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Publication Detail:
Type:  Journal Article     Date:  2009-06-11
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  81     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  89-96     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Helsinki, P.O. Box 9 (Siltavuorenpenger 20), FIN-00014, Helsinki, Finland. Marja.Laasonen@helsinki.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Attention Deficit Disorder with Hyperactivity / blood*,  epidemiology
Comorbidity
Dyslexia / blood*,  epidemiology
Fatty Acids / blood*
Fatty Acids, Omega-3 / blood
Fatty Acids, Omega-6 / blood
Fatty Acids, Unsaturated / blood
Female
Finland / epidemiology
Humans
Male
Middle Aged
Questionnaires
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated

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