| Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS). | |
| | |
MedLine Citation:
|
PMID: 21959959 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIMS: Associations of proinsulin-to-insulin ratios with incident type 2 diabetes have been inconsistent. The use of C-peptide as the denominator in the ratio may allow for better prediction because C-peptide concentration is not affected by hepatic insulin clearance. The objective of this paper was to compare fasting intact and split proinsulin-to-insulin ratios (PI/I, SPI/I) with intact and split proinsulin-to-C-peptide ratios (PI/C-pep, SPI/C-pep) in the prediction of type 2 diabetes. METHODS: Prospective data on 818 multi-ethnic adults without diabetes at baseline from the Insulin Resistance Atherosclerosis Study (IRAS) were used. Insulin sensitivity (S(I)) and acute insulin response (AIR) were determined from frequently sampled intravenous glucose tolerance tests, and fasting intact and split proinsulin were measured using specific two-site monoclonal antibody-based immunoradiometric assays. Associations of proinsulin ratios with type 2 diabetes were determined using logistic regression and differences in prediction were assessed by comparing areas under the receiver operating characteristic curve (AROCs). RESULTS: In logistic regression analyses, PI/C-pep and SPI/C-pep were more strongly associated with incident type 2 diabetes (n = 128) than PI/I and SPI/I, and were significantly better predictors of diabetes in AROC analyses (PI/C-pep = 0.662 vs PI/I = 0.603, p = 0.02; SPI/C-pep = 0.690 vs SPI/I = 0.631, p = 0.01). Both PI/C-pep and SPI/C-pep were associated with type 2 diabetes after adjustment for age, sex, ethnicity, waist circumference, impaired glucose tolerance, lipids and S(I). Both PI/C-pep and SPI/C-pep were significantly associated with incident type 2 diabetes in models that included AIR. CONCLUSIONS: Proinsulin-to-C-peptide ratios were stronger predictors of diabetes in comparison with proinsulin-to-insulin ratios. These findings support the use of C-peptide as the denominator for proinsulin ratios, to more accurately reflect the degree of disproportional hyperproinsulinaemia. |
| | |
Authors:
|
R C Loopstra-Masters; S M Haffner; C Lorenzo; L E Wagenknecht; A J Hanley |
Related Documents
:
|
22149369 - A review of gliptins in 2011. 2650739 - Electric charge distribution in proteins and ionic strength dependence of reaction rate. 1111399 - The early detection of airway obstruction. 21871459 - Effects of dpp-4 inhibition on cardiac metabolism and function in mice. 92619 - Instability of cerebral blood-flow in insulin-dependent diabetics. 8227479 - Effects of pyrazinoylguanidine on the glucose-fatty acid cycle in normal subjects and p... 10435649 - Effect of continuous glucose therapy begun in infancy on the long-term clinical course ... 12831339 - Insulin analogues and other developments in insulin therapy for diabetes. 14687899 - Influence of fibrate treatment on malondialdehyde-modified ldl concentration. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-30 |
Journal Detail:
|
Title: Diabetologia Volume: - ISSN: 1432-0428 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, FitzGerald Building, 150 College St, Toronto, ON, Canada, M5S 3E2. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Do men develop type 2 diabetes at lower body mass indices than women?
Next Document: 1-Million droplet array with wide-field fluorescence imaging for digital PCR.