| Proinflammatory syndrome mimicking acute rheumatoid arthritis in a patient with Waldenstrom's macroglobulinemia treated with rituximab. | |
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MedLine Citation:
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PMID: 14513285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute adverse reactions to rituximab treatment have been previously described in association with initiation of therapy. We describe a novel delayed proinflammatory syndrome which occurred at, or near, the completion of a 4-week dose-intense course with rituximab in a 58-year-old man with Waldenstrom's macroglobulinemia, and which mimicked acute rheumatoid arthritis affecting the hands and the knees. This syndrome was associated with an increase in acute phase reactants, and the clinical symptoms were temporally reproducible, although decreased in severity, with subsequent rituximab therapy, and each time responded to prednisone. This is the first report on an acute rheumatoid-like flare occurring in association with rituximab therapy. This phenomenon is all the more intriguing in that rituximab has been used to treat refractory rheumatoid arthritis. Potential etiologic mechanisms and management of this newly described phenomenon are discussed. |
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Authors:
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E M Buda-Okreglak; J J Drabick; N R Delaney |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2003-09-25 |
Journal Detail:
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Title: Annals of hematology Volume: 83 ISSN: 0939-5555 ISO Abbreviation: Ann. Hematol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-14 Completed Date: 2004-03-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 117-9 Citation Subset: IM |
Affiliation:
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Hematology/Oncology Service, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA. Edwarda.Buda-Okreglak@na.amedd.army.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antinuclear
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blood Antibodies, Monoclonal / adverse effects*, therapeutic use Antineoplastic Agents / adverse effects, therapeutic use Arthritis, Rheumatoid / chemically induced, diagnosis* C-Reactive Protein / analysis Diagnosis, Differential Humans Inflammation / blood, chemically induced, diagnosis* Leukocytes Male Middle Aged Rheumatoid Factor / blood Syndrome Waldenstrom Macroglobulinemia / blood, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Antibodies, Monoclonal; 0/Antineoplastic Agents; 0/rituximab; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor |
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