Document Detail

Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up.
MedLine Citation:
PMID:  22353926     Owner:  NLM     Status:  Publisher    
BACKGROUND/OBJECTIVES:This study examined the effect of weight loss after 3, 6 and 12 months of Roux-en-Y Gastric Bypass (RYGB) on energy intake and on several biomarkers of oxidative stress such as levels of vitamin C, beta-carotene, vitamin E (diet/blood), nitric oxide metabolites (NOx), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and activity of catalase (CAT).SUBJECTS/METHODS:Study with a control group (CG), assessed once, and a bariatric group (BG) assessed at the basal period as well as at 3, 6 and 12 months post-surgery; both groups were composed of 5 men and 31 women (n=36). Age was 38.7±9.4 and 39.6±9.2 years old and body mass index (BMI) was 22.2±2.1 and 47.6±9.1 kg/m(2), respectively. The variance measure quoted was SEM.RESULTS:The body weight at 12 months was 35.8±1.0% (P<0.001) lower than that of the basal period. At the basal period BG showed higher levels of NOx (P=0.007) and TBARS (P<0.001) and lower levels of vitamins C and E (P<0.001) compared with CG. After 3 months the activity of MPO was decreased (P<0.001). Six months after surgery GSH levels were decreased (P=0.037), whereas CAT activity was increased (P=0.029). After 12 months levels of NOx (P=0.004), TBARS (P<0.001), beta-carotene (P<0.001) and vitamin E (P<0.001) were decreased, whereas those of vitamin C (P<0.001) were increased compared with controls.CONCLUSION:RYGB followed by a daily vitamin supplement apparently attenuated pro-inflammatory and oxidative stress markers 1 year after surgery, but additional antioxidant supplementation appears necessary.European Journal of Clinical Nutrition advance online publication, 22 February 2012; doi:10.1038/ejcn.2012.17.
V R G da Silva; E A M Moreira; D Wilhelm-Filho; J X de Miranda; J P Benincá; S V G Vigil; A M B Moratelli; T R Garlet; M S de Souza Meirelles; H Vannucchi; T S Fröde
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-22
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  -     ISSN:  1476-5640     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Post-Graduate Programme in Nutrition, Federal University of Santa Catarina, Santa Catarina, Brazil.
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