Document Detail

Proinflammatory mediators in nasal lavage of subjects with occupational rhinitis.
MedLine Citation:
PMID:  20647139     Owner:  NLM     Status:  MEDLINE    
We sought to investigate the type and kinetics of late-phase nasal inflammatory response after nasal challenge with occupational allergens. Participants were 10 subjects experiencing work-related rhinitis symptoms who underwent specific inhalation challenge and tested positive for occupational rhinitis. During challenge, we monitored changes in inflammatory cells, eosinophil cationic protein, myeloperoxidase, and interleukin-8 in nasal lavage samples. The challenge with the active agent induced a significant increase in the percentage of eosinophils at 30 minutes as compared with prechallenge values (P = 0.04). A significant increase in eosinophil cationic protein levels after challenge with the control (P = 0.01) and active agent (P = 0.02) was observed in the late phase after challenge. No significant changes in nasal levels of neutrophils, myeloperoxidase, and interleukin-8 were observed on both control and active challenge days. Our results suggest a predominant nasal eosinophilic inflammatory response after occupational allergen challenge.
Roberto Castano; Karim Maghni; Lucero Castellanos; Carole Trudeau; Jean-Luc Malo; Denyse Gautrin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  143     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-3.e1     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
Hôpital du Sacré-Coeur de Montréal, Montréal, Quebec, Canada.
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MeSH Terms
Administration, Inhalation
Analysis of Variance
Enzyme-Linked Immunosorbent Assay
Eosinophil Cationic Protein / metabolism
Inflammation Mediators / metabolism*
Interleukin-8 / metabolism
Lactose / administration & dosage
Occupational Exposure / adverse effects*
Peroxidase / metabolism
Respiratory Hypersensitivity / immunology,  metabolism*
Rhinitis, Allergic, Perennial / immunology,  metabolism*
Skin Tests
Statistics, Nonparametric
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-8; 63-42-3/Lactose; EC; EC 3.1.27.-/Eosinophil Cationic Protein

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