| Proinflammatory mediators in nasal lavage of subjects with occupational rhinitis. | |
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MedLine Citation:
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PMID: 20647139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to investigate the type and kinetics of late-phase nasal inflammatory response after nasal challenge with occupational allergens. Participants were 10 subjects experiencing work-related rhinitis symptoms who underwent specific inhalation challenge and tested positive for occupational rhinitis. During challenge, we monitored changes in inflammatory cells, eosinophil cationic protein, myeloperoxidase, and interleukin-8 in nasal lavage samples. The challenge with the active agent induced a significant increase in the percentage of eosinophils at 30 minutes as compared with prechallenge values (P = 0.04). A significant increase in eosinophil cationic protein levels after challenge with the control (P = 0.01) and active agent (P = 0.02) was observed in the late phase after challenge. No significant changes in nasal levels of neutrophils, myeloperoxidase, and interleukin-8 were observed on both control and active challenge days. Our results suggest a predominant nasal eosinophilic inflammatory response after occupational allergen challenge. |
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Authors:
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Roberto Castano; Karim Maghni; Lucero Castellanos; Carole Trudeau; Jean-Luc Malo; Denyse Gautrin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 143 ISSN: 1097-6817 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 301-3.e1 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Hôpital du Sacré-Coeur de Montréal, Montréal, Quebec, Canada. roberto.castano@mail.mcgill.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Analysis of Variance Enzyme-Linked Immunosorbent Assay Eosinophil Cationic Protein / metabolism Female Humans Inflammation Mediators / metabolism* Interleukin-8 / metabolism Irrigation Lactose / administration & dosage Male Neutrophils Occupational Exposure / adverse effects* Peroxidase / metabolism Respiratory Hypersensitivity / immunology, metabolism* Rhinitis, Allergic, Perennial / immunology, metabolism* Skin Tests Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators; 0/Interleukin-8; 63-42-3/Lactose; EC 1.11.1.7/Peroxidase; EC 3.1.27.-/Eosinophil Cationic Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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