| Proinflammatory doses of diesel exhaust in healthy subjects fail to elicit equivalent or augmented airway inflammation in subjects with asthma. | |
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MedLine Citation:
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PMID: 20837873 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Exposure to traffic-derived air pollutants, particularly diesel emissions, has been associated with adverse health effects, predominantly in individuals with pre-existing respiratory disease. Here the hypothesis that this heightened sensitivity reflects an augmentation of the transient inflammatory response previously reported in healthy adults exposed to diesel exhaust is examined. Methods 32 subjects with asthma (mild to moderate severity) and 23 healthy controls were exposed in a double-blinded crossover control fashion to both filtered air and diesel exhaust (100 μg/m(3) PM(10)) for 2 h. Airway inflammation was assessed by bronchoscopy 18 h postexposure. In addition, lung function, fraction of exhaled nitric oxide and bronchial reactivity to metacholine were examined in the subjects with asthma. Results In healthy control subjects a significant increase in submucosal neutrophils (p=0.004) was observed following the diesel challenge. Significant increases in neutrophil numbers (p=0.01), and in the concentrations of interleukin 6 (p=0.03) and myeloperoxidase (p=0.04), were also seen in bronchial wash after diesel, relative to the control air challenge. No evidence of enhanced airway inflammation was observed in the subjects with asthma following the diesel exposure. Conclusions Exposure to diesel exhaust at concentrations consistent with roadside levels elicited an acute and active neutrophilic inflammation in the airways of healthy subjects. This response was absent in subjects with asthma, as was evidence supporting a worsening of allergic airway inflammation. |
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Authors:
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Annelie F Behndig; Nirina Larsson; Joanna L Brown; Nikolai Stenfors; Ragnberth Helleday; Sean T Duggan; Rosamund E Dove; Susan J Wilson; Thomas Sandstrom; Frank J Kelly; Ian S Mudway; Anders Blomberg |
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Publication Detail:
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Type: Journal Article Date: 2010-09-13 |
Journal Detail:
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Title: Thorax Volume: 66 ISSN: 1468-3296 ISO Abbreviation: Thorax Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
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Languages: eng Pagination: 12-9 Citation Subset: IM |
Affiliation:
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King's College London, MRC-HPA Centre for Environment and Health, School of Biomedical and Health Sciences, 4th Floor Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. ian.mudway@kcl.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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