Document Detail

Proinflammatory cytokines in heart disease.
MedLine Citation:
PMID:  11244192     Owner:  NLM     Status:  MEDLINE    
Proinflammatory cytokines affect nearly all tissues and organ systems, and the vasculature is no exception. Although a considerable amount of research has focused on the role of the two most prominent proinflammatory cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), in the pathogenesis of sepsis and septic shock, the role of these and other cytokines in the pathogenesis of atherosclerotic lesions of the coronary artery, the acute ischemic event associated with myocardial infarction, the progression of myocardiopathies or the loss of myocardial function in congestive heart failure is a relatively recent discovery. Moreover, there has also been significant investigation of the cardioprotective effects of cytokines. Most of the attention has focused on the acute coronary syndromes and the myocardial suppression that takes place as a result of acute ischemia. The potential for anticytokine-based therapies in treating heart disease is great. Parenteral TNF-alpha neutralization and IL-1 receptor blockade are presently used to treat rheumatoid arthritis. Two orally effective agents, the IL-1beta-converting enzyme inhibitor and the mitogen-activating protein kinase p38 inhibitor, are currently being investigated in clinical trials.
C A Dinarello; B J Pomerantz
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Blood purification     Volume:  19     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-13     Completed Date:  2001-06-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  314-21     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel.
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
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MeSH Terms
Cytokines / blood,  immunology*
Heart Diseases / blood,  immunology*
Grant Support
Reg. No./Substance:

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