Document Detail


Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: a comparison with younger-onset disease.
MedLine Citation:
PMID:  18849599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Little is known about the differences in the immunopathogenesis between elderly-onset rheumatoid arthritis (EORA) and younger-onset RA (YORA) and the factors responsible for their clinical characteristics. OBJECTIVE: It was the aim of this study to investigate proinflammatory cytokines of EORA patients and compare them with those of YORA patients. METHODS: Serum levels of interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma were determined by cytometric bead array in 86 patients with active EORA, in 76 patients with active YORA and in 30 healthy controls. Disease activity of RA was assessed using the 28-joint disease activity score. Erosion scores were recorded using a modified version of the Sharp method. Levels of anti-cyclic citrullinated peptide antibodies were determined by ELISA, and levels of rheumatoid factor-IgM and C-reactive protein were measured by nephelometry. RESULTS: A higher proportion of men and a higher frequency of acute onset with constitutional symptoms and comorbidities were observed in EORA compared with YORA patients. Increased levels of serum IL-1beta, IL-6, TNF-alpha, IFN-gamma and IL-8 were positively correlated with the 28-joint disease activity score, and elevated levels of IL-1beta and TNF-alpha were positively correlated with erosion scores for both groups of RA patients. Significantly higher IL-6 levels and lower TNF-alpha levels were found in EORA compared with YORA patients. Higher levels of serum IL-6 were found in EORA patients with polymyalgia rheumatica-like symptoms than in those without and were also noted in male patients with EORA compared with female patients. Multivariate analysis showed that high levels of TNF-alpha were associated with the occurrence of constitutional symptoms, and high levels of IL-1beta were associated with the presence of anti-cyclic citrullinated peptide antibodies in EORA patients. CONCLUSION: EORA patients appear to have differences in clinical characteristics and the patterns of proinflammatory cytokines when compared with YORA patients.
Authors:
Der-Yuan Chen; Tsu-Yi Hsieh; Yi-Ming Chen; Chia-Wie Hsieh; Joung-Liang Lan; Fang-Ju Lin
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-10-13
Journal Detail:
Title:  Gerontology     Volume:  55     ISSN:  1423-0003     ISO Abbreviation:  Gerontology     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  250-8     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Affiliation:
Division of Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Aged, 80 and over
Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / blood*,  diagnosis,  drug therapy,  immunology
Case-Control Studies
Citrulline / immunology*
Cytokines / blood*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Peptides, Cyclic / immunology*
Rheumatoid Factor / analysis
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antirheumatic Agents; 0/Cytokines; 0/Peptides, Cyclic; 372-75-8/Citrulline; 9009-79-4/Rheumatoid Factor

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