Document Detail

Proinflammatory and anti-inflammatory cytokine gene polymorphisms in hypersensitivity pneumonitis.
MedLine Citation:
PMID:  16722148     Owner:  NLM     Status:  MEDLINE    
Hypersensitivity pneumonitis (HP) is an immunologically-mediated lung disease caused by repeated inhalation of dispersed antigen. Various cytokines have been reported to be involved in the immunopathogenesis of HP Recently, some reports suggested an association between the genetic control of cytokine production and disease susceptibility. To evaluate whether cytokine gene polymorphisms are associated with HP, we performed a case-control association study involving 61 patients with HP, consisting of summer-type HP (SHP) and bird fancier's lung (BFL, also named bird fancier's disease), as well as 101 healthy controls. Polymorphisms of the genes for tumor necrosis factor (TNF)-alpha (-308G/A, -857C/T, -863C/A, -1031T/C), interleukin (IL)-10 (-592C/A, -819C/T, -1082G/A), transforming growth factor (TGF)-beta1 (-509C/T, +869T/C), and IL-6 (-634C/G) were examined by restriction fragment length polymorphism analysis. There were no significant differences in allele frequency and genotype distribution among control, SHP, and BFL group. When HP group was divided into acute or chronic, no significant differences were detected between any groups. LPS-stimulated IL-6 secretion by whole blood cells was similar between subjects with GG genotype and non-GG genotype in IL-6 -634C/G polymorphism. In conclusion, the association between HP susceptibility and cytokine polymorphisms studied was not demonstrated.
Kyoko Kondoh; Yutaka Usui; Yoshio Ohtani; Naohiko Inase; Shuji Miyake; Yasuyuki Yoshizawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical and dental sciences     Volume:  53     ISSN:  1342-8810     ISO Abbreviation:  J. Med. Dent. Sci.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-06-20     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  9717112     Medline TA:  J Med Dent Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  75-83     Citation Subset:  D; IM    
Department of Integrated Pulmonology, Graduate School, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Alveolitis, Extrinsic Allergic / blood,  genetics*
Bird Fancier's Lung / blood,  genetics
Case-Control Studies
Cytokines / genetics*
Gene Frequency
Genetic Predisposition to Disease
Interleukin-10 / genetics
Interleukin-6 / genetics
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Statistics, Nonparametric
Transforming Growth Factor beta / genetics
Transforming Growth Factor beta1
Tumor Necrosis Factor-alpha / genetics
Reg. No./Substance:
0/Cytokines; 0/Interleukin-6; 0/TGFB1 protein, human; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

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