Document Detail


Prohepcidin concentrations and erythroid progenitors in cord blood of appropriate versus small for gestational age neonates.
MedLine Citation:
PMID:  19890342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Prohepcidin (Pro-Hep), synthesized in the liver, is the prohormone of hepcidin (Hep), which reduces iron absorption in the gut; its synthesis is enhanced by inflammation and is reduced during hypoxia. We aimed to study the hypothesis that infants born small for gestational age (SGA) have reduced cord blood concentrations of Pro-Hep. STUDY DESIGN: Cord blood was collected from 20 SGA (term and near term >35 week gestation) infants and 20 appropriate for gestational age (AGA) controls. We excluded infants exposed to maternal chronic diseases, smoking, diabetes, alcohol or drug use. Both groups had a 1 min Apgar score above or equal to 7 and had normal cord blood pH (above 7.25). ELISA was used to determine serum concentrations of Pro-Hep and erythropoietin (EPO). Circulating CD71(+)/CD45(-)/SSC(low) cells were measured by flow cytometry as an index of erythroid progenitors. RESULT: There were no significant differences between groups in terms of hemoglobin concentrations, and Pro-Hep. In contrast, EPO levels and circulating CD71(+)/CD45(-)/SSC(low) erythroid progenitors were significantly higher in the SGA group. These differences remained significant even after controlling for gestational age and gravidity. CONCLUSION: Contrary to EPO upregulation during intrauterine growth restriction (IUGR), and higher concentrations of circulating erythroid progenitors, Pro-Hep concentration is not affected by IUGR.
Authors:
G Amarilyo; F B Mimouni; A Oren; Y Ochshorn; A Ballin; V Deutsch; D Mandel
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-11-05
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396-8     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antimicrobial Cationic Peptides / blood*
Erythrocyte Count*
Erythroid Cells
Erythropoietin / blood*
Female
Fetal Blood*
Fetal Growth Retardation / blood*
Humans
Infant, Newborn
Infant, Small for Gestational Age / blood*
Prospective Studies
Protein Precursors / blood*
Stem Cells
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Protein Precursors; 0/prohepcidin; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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